Document Detail


Ongoing normal pregnancy after transfer of zona-free blastocysts: implications for embryo transfer in the human.
MedLine Citation:
PMID:  9130759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Recent reports suggest that transfer of day 5 blastocysts improves implantation rates in in-vitro fertilization programmes. This paper reports a successful ongoing pregnancy after the transfer of zona-free day 6 expanded and hatching blastocysts. The patient was 37 years old and had undergone six stimulated and two thaw cycles previously, all of which had failed. Stimulation was by down-regulation and oocytes recovered transvaginally by ultrasound guidance. Two pronuclear embryos were co-cultured on Vero cells to day 6. The zonae of two hatching and two fully expanded blastocysts were removed using 0.5% pronase, and the zona-free blastocysts were then transferred. Pregnancy was confirmed on day 18 with a positive human chorionic gonadotrophin (HCG) and ultrasound at 6 weeks showed a single healthy fetal heart inside a clear sac. At 14 weeks a triple test (oestriol, J-HCG and alpha-fetoprotein) was normal and at 22 weeks a detailed ultrasound scan showed no congenital anomalies. This is the first report in the human of a normal ongoing pregnancy after the transfer of zona-free day 6 embryos.
Authors:
C Y Fong; A Bongso; S C Ng; C Anandakumar; A Trounson; S Ratnam
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  12     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-07-29     Completed Date:  1997-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  557-60     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
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MeSH Terms
Descriptor/Qualifier:
Adult
Blastocyst
Embryo Transfer / methods*
Female
Fertilization in Vitro / methods*
Humans
Male
Pregnancy
Ultrasonography, Prenatal
Zona Pellucida / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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