Document Detail

Ongoing normal pregnancy after transfer of zona-free blastocysts: implications for embryo transfer in the human.
MedLine Citation:
PMID:  9130759     Owner:  NLM     Status:  MEDLINE    
Recent reports suggest that transfer of day 5 blastocysts improves implantation rates in in-vitro fertilization programmes. This paper reports a successful ongoing pregnancy after the transfer of zona-free day 6 expanded and hatching blastocysts. The patient was 37 years old and had undergone six stimulated and two thaw cycles previously, all of which had failed. Stimulation was by down-regulation and oocytes recovered transvaginally by ultrasound guidance. Two pronuclear embryos were co-cultured on Vero cells to day 6. The zonae of two hatching and two fully expanded blastocysts were removed using 0.5% pronase, and the zona-free blastocysts were then transferred. Pregnancy was confirmed on day 18 with a positive human chorionic gonadotrophin (HCG) and ultrasound at 6 weeks showed a single healthy fetal heart inside a clear sac. At 14 weeks a triple test (oestriol, J-HCG and alpha-fetoprotein) was normal and at 22 weeks a detailed ultrasound scan showed no congenital anomalies. This is the first report in the human of a normal ongoing pregnancy after the transfer of zona-free day 6 embryos.
C Y Fong; A Bongso; S C Ng; C Anandakumar; A Trounson; S Ratnam
Related Documents :
15568359 - Effect of horizontal transfer of barrier insecticides to control argentine ants (hymeno...
15151729 - Effect of treatment of intrauterine pathologies with office hysteroscopy in patients wi...
14989799 - Determining the most optimal stage for embryo cryopreservation.
14649499 - Biofluid aspects of embryo transfer.
20133199 - Altered first-trimester screening markers after ivf/icsi: no relationship with small-fo...
14604439 - Ectopic pregnancy rates with day 3 versus day 5 embryo transfer: a retrospective analysis.
16933359 - Cardiac axis in fetuses with abdominal wall defects.
11429639 - Hormones and calcium: mechanisms controlling uterine smooth muscle contractile activity...
17377899 - Ectopic pregnancies in unusual locations.
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Human reproduction (Oxford, England)     Volume:  12     ISSN:  0268-1161     ISO Abbreviation:  Hum. Reprod.     Publication Date:  1997 Mar 
Date Detail:
Created Date:  1997-07-29     Completed Date:  1997-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701199     Medline TA:  Hum Reprod     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  557-60     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, National University Hospital, Singapore.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Embryo Transfer / methods*
Fertilization in Vitro / methods*
Ultrasonography, Prenatal
Zona Pellucida / physiology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Successful fertilization and pregnancy after injection of frozen-thawed round spermatids into human ...
Next Document:  Rat myometrial smooth muscle cells express endothelial nitric oxide synthase.