| Ongoing myocardial damage in patients with heart failure and preserved ejection fraction. | |
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MedLine Citation:
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PMID: 22819040 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: The relationship between ongoing myocardial damage and heart failure with preserved left ventricular systolic function (HF-PEF) is still unclear. To investigate this relationship, we measured the cardiac-specific cytosolic marker, heart-type fatty acid binding protein (H-FABP), and a myofibrillar component (troponin T), and analyzed clinical outcomes. METHODS AND RESULTS: Consecutive heart failure patients (n=151) with echocardiographic left ventricular ejection fraction >50% were prospectively enrolled. The cut-off values for myocardial membrane injury (H-FABP >4.3ng/mL) and myofibrillar injury (troponin T >0.01ng/mL) were defined using receiver operating characteristic curves. Myocardial membrane injury was observed more frequently than myofibrillar injury (41% vs. 26% of patients, p<0.05). Patients were followed up for a median of 694days, with the end-points being cardiovascular death or re-hospitalization. By multivariate analysis, the serum H-FABP level was an independent predictor of cardiovascular events (hazard ratio 1.165 per 1ng/mL increase, 95% confidence interval 1.034-1.314, p=0.012). CONCLUSIONS: Latent myocardial injury was frequently observed in patients with HF-PEF. The circulating H-FABP level was an independent predictor of subsequent cardiovascular events. |
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Authors:
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Daisuke Kutsuzawa; Takanori Arimoto; Tetsu Watanabe; Tetsuro Shishido; Takuya Miyamoto; Takehiko Miyashita; Hiroki Takahashi; Takeshi Niizeki; Yasuchika Takeishi; Isao Kubota |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-19 |
Journal Detail:
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Title: Journal of cardiology Volume: - ISSN: 1876-4738 ISO Abbreviation: - Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-7-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8804703 Medline TA: J Cardiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Japanese College of Cardiology. Published by Elsevier Ltd. All rights reserved. |
Affiliation:
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The Department of Cardiology, Pulmonology, and Nephrology, Yamagata University School of Medicine, Yamagata, Japan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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