Document Detail


Ongoing cell death and immune influences on regeneration in the vestibular sensory organs.
MedLine Citation:
PMID:  11710476     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Hair cells in the vestibular organs of birds have a relatively short life span. Mature hair cells appear to die spontaneously and are then quickly replaced by new hair cells that arise from the division of epithelial supporting cells. A similar regenerative mechanism also results in hair cell replacement after ototoxic damage. The cellular basis of hair cell turnover in the avian ear is not understood. We are investigating the signaling pathways that lead to hair cell death and the relationship between ongoing cell death and cell production. In addition, work from our lab and others has demonstrated that the avian inner ear contains a resident population of macrophages and that enhanced numbers of macrophages are recruited to sites of hair cells lesions. Those observations suggest that macrophages and their secretory products (cytokines) may be involved in hair cell regeneration. Consistent with that suggestion, we have found that treatment with the anti-inflammatory drug dexamethasone reduces regenerative cell proliferation in the avian ear, and that certain macrophage-secreted cytokines can influence the proliferation of vestibular supporting cells and the survival of statoacoustic neurons. Those results suggest a role for the immune system in the process of sensory regeneration in the inner ear.
Authors:
M E Warchol; J I Matsui; E L Simkus; J M Ogilive
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Annals of the New York Academy of Sciences     Volume:  942     ISSN:  0077-8923     ISO Abbreviation:  Ann. N. Y. Acad. Sci.     Publication Date:  2001 Oct 
Date Detail:
Created Date:  2001-11-16     Completed Date:  2001-12-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7506858     Medline TA:  Ann N Y Acad Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  34-45     Citation Subset:  IM; S    
Affiliation:
Fay and Carl Simons Center for Biology of Hearing and Deafness, Central Institute for the Deaf, St. Louis, Missouri 63110, USA. mwarchol@cid.wustl.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Apoptosis*
Birds
Cell Division / drug effects,  immunology*
Dexamethasone / pharmacology
Hair Cells, Vestibular / cytology,  immunology,  physiology*
Macrophages / cytology
Neomycin / pharmacology
Saccule and Utricle / cytology,  drug effects
Chemical
Reg. No./Substance:
1404-04-2/Neomycin; 50-02-2/Dexamethasone
Investigator
Investigator/Affiliation:
M E Warchol / Cent Inst Deaf, St Louis, MO

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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