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One-year weight losses in the TRAMOMTANA Study. A Randomized Controlled Trial.
MedLine Citation:
PMID:  23163735     Owner:  NLM     Status:  Publisher    
BACKGROUND: Morbid obesity is a major health problem and bariatric surgery is currently the most effective therapy available to induce weight loss in these patients. This report describes 1-year changes in weight and metabolic parameters, in a trial designed to examine the effects of a non-surgical approach, Intensive Life style Intervention (ILI) on the therapy of morbid obesity. METHODS: The primary outcome was change in body weight. Patients were randomized to ILI (n=60) or conventional obesity therapy (COT) (n=46). The ILI group received behavioural therapy and nutritional/physical activity counseling. The COT group received the standard medical treatment available for these patients. A third group consisted of the patients already included in our bariatric surgery waiting list (n=37). FINDINGS: We present here one year data showing that patients who received ILI with no restrictions in calorie intake had a greater percentage of weight loss than patients receiving COT (-11.58% vs. -0.4%; p<.001). Importantly, 31.4% of patients included in the ILI group were not morbidly obese after 6 months of intervention. This number increased to 42.8% after 12 months of intervention. INTERPRETATION: ILI was associated with significant weight loss compared to COT in a group of morbidly obese patients. The weight loss effect was already obtained after 6 months of ILI intervention. These results seriously question the efficacy of the COT approach to morbid obesity. Furthermore, they underscore the use of ILI programs in the hospital setting to effectively treat morbidly obese patients and might help to reduce the number of candidate patients for bariatric surgery. © 2012 Blackwell Publishing Ltd.
Juan Jesús Tur; Antonio Jorge Escudero; María Micaela Alos; Ramón Salinas; Emma Terés; Joan B Soriano; Gabriela Nicola; Juan Ramón Urgelés; Alberto Pagán; Baltasar Cortes; Xavier González; Bartolomé Burguera
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-20
Journal Detail:
Title:  Clinical endocrinology     Volume:  -     ISSN:  1365-2265     ISO Abbreviation:  Clin. Endocrinol. (Oxf)     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0346653     Medline TA:  Clin Endocrinol (Oxf)     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Grupo de Obesidad y Diabetes, Instituto Universitario de Investigación en Ciencias de la Salud de les Illes Balears- (IUNICS), Palma de Mallorca, Spain; Unidad de Investigación-CAIBER, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
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