Document Detail

One-year results of bevacizumab intravitreal and posterior sub-Tenon injection of triamcinolone acetonide with reduced laser fluence photodynamic therapy for retinal angiomatous proliferation.
MedLine Citation:
PMID:  22990616     Owner:  NLM     Status:  MEDLINE    
PURPOSE: Our aim was to study the efficacy of combined triple therapy with intravitreal bevacizumab injections (IVB), posterior sub-Tenon injection of triamcinolone acetonide (STTA), and reduced laser fluence photodynamic therapy (RFPDT) in Japanese patients with retinal angiomatous proliferation (RAP).
DESIGN: This was a retrospective, observational, consecutive case series.
METHODS: Fifteen consecutive RAP treatment-naïve eyes were treated with triple therapy of IVB, STTA, and RFPDT (25 J/cm(2) of laser fluence). Whenever there was a recurrence of retinal-retinal anastomosis (RRA) or retinal-choroidal anastomosis (RCA) and marked leakage from subretinal neovascularization, the triple therapy was reapplied. When there were only intraretinal exudative and/or hemorrhagic changes without distinct RRA or RCA, IVB alone was applied.
RESULTS: The mean logarithm of the minimum angle of resolution (logMAR) best-corrected visual acuity (BCVA) at baseline improved significantly (from 0.489 to 0.294 12 months) (paired t test, p = 0.043). LogMAR BCVA at 12 months was stable or improved by ≥ 0.2 in 14 eyes (93.3 %). Mean number of triple therapy instituted during the 12-month study period was 1.2, and mean number of IVB treatments was 1.4.
CONCLUSION: Combined IVB, STTA, and RFPDT for RAP was effective in maintaining or improving VA at 1 year. In addition, the number of treatments could be markedly reduced.
Yukari Shirakata; Chieko Shiragami; Ayana Yamashita; Eri Nitta; Atsushi Fujiwara; Fumio Shiraga
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2012-09-19
Journal Detail:
Title:  Japanese journal of ophthalmology     Volume:  56     ISSN:  1613-2246     ISO Abbreviation:  Jpn. J. Ophthalmol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-02-01     Revised Date:  2013-05-27    
Medline Journal Info:
Nlm Unique ID:  0044652     Medline TA:  Jpn J Ophthalmol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  599-607     Citation Subset:  IM    
Department of Ophthalmology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe Miki-cho, Kagawa 761-0793, Japan.
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MeSH Terms
Aged, 80 and over
Angiogenesis Inhibitors / administration & dosage*
Antibodies, Monoclonal, Humanized / administration & dosage*
Coloring Agents / diagnostic use
Combined Modality Therapy
Fluorescein Angiography
Glucocorticoids / administration & dosage*
Indocyanine Green / diagnostic use
Intravitreal Injections
Retinal Neovascularization / drug therapy*,  physiopathology
Retrospective Studies
Tenon Capsule / drug effects
Tomography, Optical Coherence
Treatment Outcome
Triamcinolone Acetonide / administration & dosage*
Vascular Endothelial Growth Factor A / antagonists & inhibitors
Visual Acuity / physiology
Wet Macular Degeneration / drug therapy*,  physiopathology
Reg. No./Substance:
0/Angiogenesis Inhibitors; 0/Antibodies, Monoclonal, Humanized; 0/Coloring Agents; 0/Glucocorticoids; 0/VEGFA protein, human; 0/Vascular Endothelial Growth Factor A; 2S9ZZM9Q9V/bevacizumab; 3599-32-4/Indocyanine Green; 76-25-5/Triamcinolone Acetonide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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