Document Detail

One-year pilot study on tauroursodeoxycholic acid as an adjuvant treatment after liver transplantation.
MedLine Citation:
PMID:  10575563     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The usefulness of ursodeoxycholic acid after liver transplantation is controversial. Tauroursodeoxycholic acid, the natural taurine-amidate, is a highly hydrophilic and cytoprotective bile salt currently under investigation. AIMS: To investigate the clinical usefulness of tauroursodeoxycholic acid after liver transplantation. PATIENTS: Thirty-three patients undergoing liver transplantation entered the study. METHODS: Sixteen patients were randomized to receive tauroursodeoxycholic acid (250 b.i.d. for 12 months) and 17 served as controls. Tauroursodeoxycholic acid was given from day 5 after transplantation for one year. RESULTS: Tauroursodeoxycholic acid treatment was safe and well tolerated. No drop outs occurred. Among the 29 patients undergoing long-term follow-up, five deaths occurred (3 of whom in the tauroursodeoxycholic acid group), none of which was related to treatment. The one-year actuarial survival was 78.6% in patients treated with tauroursodeoxycholic acid and 86.7% in controls (n.s.). No differences were observed with respect to early or late graft function and survival, nor to acute cellular rejection. Tauroursodeoxycholic acid therapy was associated with lower serum cholesterol levels (p < 0.02) during the early postoperative months; with milder cholestasis; with a drop in biliary cholates but no changes in endogenous hydrophobic bile salts. CONCLUSIONS: Long-term treatment with low dose tauroursodeoxycholic acid after liver transplantation is safe but does not affect graft function and survival.
M Angelico; G Tisone; L Baiocchi; G Palmieri; F Pisani; S Negrini; A Anselmo; G Vennarecci; C U Casciani
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Italian journal of gastroenterology and hepatology     Volume:  31     ISSN:  1125-8055     ISO Abbreviation:  Ital J Gastroenterol Hepatol     Publication Date:    1999 Aug-Sep
Date Detail:
Created Date:  1999-12-21     Completed Date:  1999-12-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9711056     Medline TA:  Ital J Gastroenterol Hepatol     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  462-8     Citation Subset:  IM    
Department of Surgery, University of Rome Tor Vergata, Italy.
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MeSH Terms
Bile / chemistry,  drug effects
Chemotherapy, Adjuvant
Cholagogues and Choleretics / adverse effects,  pharmacology,  therapeutic use*
Follow-Up Studies
Immunosuppressive Agents / adverse effects,  pharmacology,  therapeutic use*
Liver Transplantation* / physiology,  statistics & numerical data
Middle Aged
Pilot Projects
Postoperative Care / methods*,  statistics & numerical data
Taurochenodeoxycholic Acid / adverse effects,  pharmacology,  therapeutic use*
Time Factors
Reg. No./Substance:
0/Cholagogues and Choleretics; 0/Immunosuppressive Agents; 14605-22-2/tauroursodeoxycholic acid; 516-35-8/Taurochenodeoxycholic Acid
Comment In:
Ital J Gastroenterol Hepatol. 1999 Aug-Sep;31(6):469-71   [PMID:  10575564 ]

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