| One-year outcomes with the Taxus Liberté stent in the real world: the Taxus Olympia registry (phase I). | |
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MedLine Citation:
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PMID: 18973513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The Taxus Olympia registry is a prospective, postapproval registry collecting clinical outcomes data on patients receiving the Taxus Liberté paclitaxel-eluting stent during routine interventional cardiology practice. METHODS: Between February and July 2005, 529 patients receiving the Taxus Liberté stent at 16 centers in the Middle East, South/Central America, and Asia/Pacific regions were enrolled in Phase I of Olympia. The primary end-point was Taxus Liberté stent-related cardiac events (cardiac death, MI, and revascularization) at 30 days postimplant. Additional clinical assessment was conducted at 6 and 12 months. Olympia phases II and III are in clinical follow-up and will be reported separately. RESULTS: One-year clinical follow-up is available for 98% of patients. Complex patients and lesions were prevalent, including: 50% diabetes mellitus, 49% multivessel disease, 30% multiple stenting, 48% AHA/ACC type B2/C lesions, 19% long lesions (>26 mm), and 40% small vessels (<or=2.75 mm). At 1 year, the cardiac event rate was 4.1%, including 1.5% cardiac death, 1.5% MI, and 2.3% target vessel revascularization (TVR). The TAXUS Liberté stent-related cardiac event rate was 3.7% at 1 year. Stent thrombosis (ST) occurred in 1.7% of patients, with three cases occurring >30 days postprocedure. One-year cardiac event rates among complex subpopulations (diabetics 5.0%, multiple stents 3.8%, long lesions 3.1%, and small vessels 2.9%) were comparable to the overall study population. CONCLUSIONS: In conclusion, this first report of real-world experience with the Taxus Liberté stent demonstrates the safety and clinical utility of this stent in the broader spectrum of coronary disease treated in everyday practice. |
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Authors:
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Waqar Habib Ahmed; Robaayah Zambahari; Ibrahim Al-Rashdan; Abdullah Al Naeemi; Fuad A Saeed; Stephen Mascioli |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-10-02 |
Journal Detail:
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Title: Journal of interventional cardiology Volume: 21 ISSN: 1540-8183 ISO Abbreviation: J Interv Cardiol Publication Date: 2008 Dec |
Date Detail:
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Created Date: 2008-11-21 Completed Date: 2009-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8907826 Medline TA: J Interv Cardiol Country: United States |
Other Details:
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Languages: eng Pagination: 512-8 Citation Subset: IM |
Affiliation:
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Armed Forces Hospital, Jeddah, Saudi Arabia. waqar@post.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Angioplasty, Balloon Angioplasty, Transluminal, Percutaneous Coronary / methods, statistics & numerical data* Asia / epidemiology Central America / epidemiology Coronary Artery Disease / mortality, therapy* Coronary Restenosis / prevention & control Drug-Eluting Stents* / adverse effects Female Heart Catheterization Humans Male Middle Aged Middle East / epidemiology Myocardial Infarction / mortality Myocardial Revascularization / methods, statistics & numerical data* Paclitaxel / administration & dosage* Product Surveillance, Postmarketing Prospective Studies Registries South America / epidemiology Taxus Treatment Outcome Tubulin Modulators / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Tubulin Modulators; 33069-62-4/Paclitaxel |
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