Document Detail

One-year outcomes of percutaneous renal denervation for the treatment of resistant hypertension: the first Chinese experience.
MedLine Citation:
PMID:  24622425     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND: As a novel device-based approach targeting the renal sympathetic nerves, percutaneous renal denervation (RDN) has been shown to be effective and safe for reducing blood pressure. However, while considerable data on RDN have been obtained from Western populations, there is limited findings from East Asian populations. The purpose of this study was to evaluate one-year outcomes of RDN for the treatment of resistant hypertension in Chinese patients.
METHODS: Between February and August 2012, 14 patients (mean age 39±8 years, 10 males) with resistant hypertension underwent successful RDN at the Fuwai Hospital. All 14 patients were followed up at 1, 3, 6 and 12 months post-procedure. Blood pressure, use of antihypertensive agents, renal function, and complications were investigated.
RESULTS: Baseline values included mean office blood pressure of 164/103±14/10 mmHg, mean 3.9±0.6 anti-hypertensive agents, and an estimated glomerular filtration rate of (79±19) ml×min(-1)×1.73 m(-2). Office blood pressure after the procedure was reduced by -14/-10, -17/-11, -21/-12, and -24/-14 mmHg at 1, 3, 6, and 12 months respectively, and the reduction of the number of antihypertensive agents at the above corresponding time points was -1.3, -1.5, -1.7 and -1.8 respectively (all P < 0.001). The mean reduction of 24-hour ambulatory blood pressure was similar to the reduction of office blood pressure at the four corresponding time points. Renal function did not significantly change at any time point (all P > 0.05). No clinical complications were observed at 12-month follow-up.
CONCLUSION: This study showed that RDN seems to be effective in reducing blood pressure of Chinese patients with resistant hypertension, with minimal adverse events at 12-month follow-up.
Hui Dong; Xiongjing Jiang; Tuo Liang; Yubao Zou; Ting Guan; Meng Peng; Lei Song; Huimin Zhang; Haiying Wu; Bo Xu; Yuejin Yang; Runlin Gao
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chinese medical journal     Volume:  127     ISSN:  0366-6999     ISO Abbreviation:  Chin. Med. J.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-03-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513795     Medline TA:  Chin Med J (Engl)     Country:  China    
Other Details:
Languages:  eng     Pagination:  1003-7     Citation Subset:  IM    
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