Document Detail

One-year outcomes of consecutive patients treated by endeavor zotarolimus and resolute zotarolimus stents, the impact of polymer coating in des technology.
MedLine Citation:
PMID:  22639426     Owner:  NLM     Status:  Publisher    
BACKGROUND: Polymer-coating represents a key component of drug-eluting stent (DES) technology and its possible impact on vessel-wall healing is a matter of debate. The clinical impact of different polymer-coating may be assessed by comparing the outcome of patients treated by DES having the same stent platform and drug, and differing in the polymer. Thus, we compared the clinical outcome of patients treated by Endeavor Zotarolimus-eluting stent (E-ZES) and Resolute Zotarolimus-eluting stent (R-ZES) as they differ in the polymer-coating only. METHODS: At our Institution, E-ZES was available during a first period and then it was substituted by the R-ZES during a second period. Clinical, angiographic and procedural data were prospectively collected. Clinical follow-up was prospectively obtained up to 1-year. Primary endpoint was the occurrence of major adverse cardiac events (MACE) at 12-month. RESULTS: A total of 467 patients undergoing PCI were enrolled: 233 patients treated with E-ZES and 234 with R-ZES. Patients treated by R-ZES had similar clinical characteristics and worse angiographic characteristics compared to those treated by E-ZES. At 12-month follow-up, MACE rate was significantly lower in the R-ZES group compared to E-ZES group (4.2% vs. 14.6%; p<0.01). This difference was due to non-significantly lower rates of death and MI and to significant lower rate of target-lesion-revascularization (R-ZES 3.4% vs. E-ZES 10.3%, p<0.01). CONCLUSIONS: The results of this study suggest that the clinical outcome of patients treated by DES differing for the polymer coating only may be different. Polymer coating is a pivotal, probably underrated, component of DES technology which may influence the clinical performance of DES. © 2012 Wiley Periodicals, Inc.
Giovanni Paolo Talarico; Francesco Burzotta; Carl Trani; Antonella Tommasino; Giampaolo Niccoli; Italo Porto; Antonio Maria Leone; Rocco Mongiardo; Giovanni Schiavoni; Filippo Crea
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-28
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  -     ISSN:  1522-726X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Institute of Cardiology, Catholic University of the Sacred Heart, Rome, Italy.
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