Document Detail

One year outcome of intensive care patients with decompensated alcoholic liver disease.
MedLine Citation:
PMID:  16849386     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: We aimed to examine the outcome of patients with decompensated alcoholic liver disease (ALD) admitted to a general intensive care unit (ICU). METHODS: Retrospective observational cohort study of intensive care admissions over a 3 yr period was conducted. The study was set in an ICU in a UK university hospital with a tertiary liver referral unit. One hundred and ten admissions, involving 107 patients, with decompensated ALD were included. Intensive care, hospital, and 6 and 12 months mortality were recorded along with the outcome in diagnostic and organ system support subgroups. Intensive care, hospital, 6 month and 12 month mortality rates were 58, 71, 78 and 81%. RESULTS: Hospital mortality in the sepsis/multiorgan failure group was 88%. Sixty-nine per cent of patients who were ventilated but required no other organ support survived to hospital discharge. However, the requirement for any other organ support, or a raised creatinine (>120 micromol litre(-1)) in the first 24 h, reduced the hospital survival to <15%. In those patients requiring acute renal replacement therapy, the hospital mortality was 94%. CONCLUSION: Decompensated ALD requiring intensive care admission is associated with a high hospital mortality and consideration should be given to the futility of escalating organ support measures, particularly when renal replacement therapy is required.
I J Mackle; D G Swann; B Cook
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Publication Detail:
Type:  Journal Article     Date:  2006-07-18
Journal Detail:
Title:  British journal of anaesthesia     Volume:  97     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-07     Completed Date:  2006-10-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  496-8     Citation Subset:  IM    
Department of Anaesthesia, Critical Care and Pain Management, The Royal Infirmary of Edinburgh at Little France, 51 Little France Crescent, Edinburgh EH16 4SA, UK.
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MeSH Terms
Aged, 80 and over
Epidemiologic Methods
Intensive Care* / methods
Liver Diseases, Alcoholic / complications,  diagnosis*,  therapy
Middle Aged
Multiple Organ Failure / etiology
Renal Replacement Therapy
Treatment Outcome

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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