Document Detail

One-year observation of inflammatory markers in patients with aortic valve stenosis who expressed high or low Chlamydia pneumoniae antibody titers.
MedLine Citation:
PMID:  23167224     Owner:  NLM     Status:  In-Process    
BACKGROUND AND AIM OF THE STUDY: Aortic valve stenosis (AVS) and atherosclerosis can be regarded as two manifestations of the same pathological process. The study aim was to evaluate annually the plasma levels of C-reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor alpha (TNFalpha) in AVS patients, and to compare these data in AVS patients with and without high IgG, IgM, and IgA titers against Chlamydia pneumoniae.
METHODS: Sixty patients with AVS who had declined the offer of remedial surgery were allocated to groups according to their antibody titers: group A (n=30, high IgG titer), group B (n=30, low IgG titer), group C (n=22, high IgA titer), group D (n=38, low IgA titer), group E (n=7, high IgM titer), and group F (n=53, low IgM titer) Antibody titers, serum levels of inflammatory markers and echocardiographic scans were monitored at 12-month intervals.
RESULTS: During a one-year observation period, a greater number of patients in group A showed AVS deterioration compared to group B (p < 0.02). The mean IgA and IgM titers in group A were higher than in group B, while mean serum CRP and IL-6 levels, and IgG titer, tended to be higher in group C compared to group D. No statistically significant differences were identified in mean serum levels of CRP, IL-6, and TNFalpha between groups A and B.
CONCLUSION: The results of the study suggested a possible association between C. pneumoniae infection and the progression of AVS.
Jolanta Swierszcz; Dubiel S Jacek; Tomasz Milewicz; Józef Krzysiek; Krystyna Sztefko; Danuta Galicka-Latała
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of heart valve disease     Volume:  21     ISSN:  0966-8519     ISO Abbreviation:  J. Heart Valve Dis.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-11-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9312096     Medline TA:  J Heart Valve Dis     Country:  England    
Other Details:
Languages:  eng     Pagination:  599-607     Citation Subset:  IM    
Second Department of Cardiology, Jagiellonian University, Collegium Medicum, Cracow, Poland.
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