Document Detail

One-year follow-up of neuropsychology, MRI, rCBF and glucose metabolism (rMRGlu) in cerebral microangiopathy.
MedLine Citation:
PMID:  10768169     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: MRI shows lacunar infarctions (LI), deep white matter lesions (DWML) and atrophy in cerebral microangiopathy, which is said to lead to vascular dementia. In a first trial series on 57 patients with confirmed pure cerebral microangiopathy (without concomitant macroangiopathy), neuropsychological impairment and (where present) brain atrophy correlated with decreased rCBF and rMRGlu. LI and DWML did not correlate with either neuropsychological impairment or decreased rCBF/rMRGlu. This study was done one year later to detect changes in any of the study parameters. METHODS: 26 patients were re-examined for rCBF, rMRGlu, LI, DWML, atrophy and neuropsychological performance (7 cognitive, 3 mnestic, 4 attentiveness tests). Using a special head holder for exact repositioning, rCBF (SPECT) and rMRGlu (PET) were measured and imaged slice by slice. White matter/cortex were quantified using MRI-defined ROIs. RESULTS: After one year the patients did not show significant decreases in rCBF or rMRGlu either in cortex or in white matter (p > 0.05), nor did any patient show LI, DWML or atrophy changes on MRI. There were no significant neuropsychological decreases (p > 0.05). CONCLUSIONS: Cerebral microangiopathy ought to show progressive neuropsychological, functional (rCBF, rMRGlu) and morphological deterioration over periods > 1 year. It is unlikely that direct cortical damage (e.g., incomplete infarction) is responsible for neuropsychological impairment since one-year follow-up of our patients revealed no progression of brain atrophy or any other cortical damage.
O Sabri; D Hellwig; M Schreckenberger; R Schneider; H J Kaiser; G Wagenknecht; K Setani; P Reinartz; M Zimny; M Mull; E B Ringelstein; U Büll
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Nuklearmedizin. Nuclear medicine     Volume:  39     ISSN:  0029-5566     ISO Abbreviation:  Nuklearmedizin     Publication Date:  2000  
Date Detail:
Created Date:  2000-05-12     Completed Date:  2000-05-12     Revised Date:  2007-01-12    
Medline Journal Info:
Nlm Unique ID:  7609387     Medline TA:  Nuklearmedizin     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  43-9     Citation Subset:  IM    
Department of Nuclear Medicine, Aachen University of Technology, Germany.
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MeSH Terms
Aged, 80 and over
Brain / blood supply,  physiopathology*,  radionuclide imaging
Cerebrovascular Circulation / physiology*
Cerebrovascular Disorders / physiopathology*,  psychology*,  radionuclide imaging
Fluorodeoxyglucose F18 / diagnostic use,  pharmacokinetics
Follow-Up Studies
Glucose / metabolism*
Middle Aged
Neuropsychological Tests*
Organ Specificity
Technetium Tc 99m Exametazime / diagnostic use,  pharmacokinetics
Time Factors
Tomography, Emission-Computed
Tomography, Emission-Computed, Single-Photon
Reg. No./Substance:
100504-35-6/Technetium Tc 99m Exametazime; 50-99-7/Glucose; 63503-12-8/Fluorodeoxyglucose F18

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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