Document Detail


One-year endurance training: effects on lung function and airway inflammation.
MedLine Citation:
PMID:  18828030     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of this study was to determine whether endurance training in athletes induces airway inflammation and pulmonary function disorders. Respiratory pattern and function were analysed in ten healthy endurance runners at rest, during sub-maximal exercise, and during the recovery. Inflammatory cells and metabolites (histamine, interleukin-8, and leukotriene E(4)) were measured in sputum at rest and after exercise. The experiments were conducted on three different occasions (basic endurance training, pre-competitive and competitive periods). In spite of the absence of post-exercise spirometric changes and respiratory symptoms, airway cells counts and inflammatory markers changed significantly. At the beginning of the experiment, athletes' induced sputum showed an abundance of macrophages compared with neutrophils. We found a high percentage of neutrophils during the pre-competitive and competitive periods of the sport season (41% and 37%), a significant increase in macrophage counts during the pre-competitive period (51%), and a significant rise in total cells, interleukin-8, leukotriene E(4), and histamine during the competitive period. In conclusion, one year's training increased markers of inflammation in the airways of endurance runners without symptoms or changes in pulmonary function, suggesting that airway inflammation is of insufficient magnitude to markedly impact lung function in healthy athletes.
Authors:
Myriam Denguezli; Imen Ben Chiekh; Helmi Ben Saad; Monia Zaouali-Ajina; Zouhaier Tabka; Zbidi Abdelkrim
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of sports sciences     Volume:  26     ISSN:  0264-0414     ISO Abbreviation:  J Sports Sci     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-14     Completed Date:  2009-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8405364     Medline TA:  J Sports Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  1351-9     Citation Subset:  IM    
Affiliation:
Department of Physiology, Faculty of Medicine, Ibn El Jazzar, Sousse, Tunisia. myriam_denguezli2@yahoo.fr
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Biological Markers
Exercise Test
Exercise Tolerance / physiology*
Humans
Inflammation / physiopathology*
Lung / physiology*
Lung Diseases / physiopathology*
Macrophages
Male
Neutrophils
Physical Endurance
Questionnaires
Respiratory Function Tests
Running / physiology*
Spirometry
Sputum / chemistry
Chemical
Reg. No./Substance:
0/Biological Markers

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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