Document Detail

One-year clinical outcome in an unselected patient population treated with the Genous™ endothelial progenitor cell capturing stent.
MedLine Citation:
PMID:  20853436     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We assessed the 1-year clinical outcome in a large cohort of unselected patients treated with an endothelial progenitor cell (EPC) capturing coronary stent.
BACKGROUND: The novel EPC capturing stent is coated with CD34+ antibodies that bind circulating EPCs to the stent surface, thereby accelerating endothelialization of the stent struts; it is hypothesized that this may prevent restenosis and stent thrombosis.
METHODS: A total of 405 unselected patients were treated percutaneously with the EPC capturing stent. The majority of patients had complex lesions with an estimated high risk of restenosis.
RESULTS: The primary endpoint defined as the composite of cardiac death, myocardial infarction (MI), and target lesion revascularization (TLR) at 1-year was 13.3%, mainly attributable to TLR which was 10.9%. The occurrence of definite and probable ST was low, 0.5 and 0.7%, respectively. Based on the risk of restenosis, in patients with an estimated high risk of restenosis (n = 249), the composite primary endpoint was 16.1% versus 9.0% in patients with an estimated low risk (n = 155). Moreover, the 1 year clinical outcomes in diabetic patient compared well with the nondiabetic patients.
CONCLUSION: In this single-center study, the 1-year clinical follow-up in a "real-world" population treated with the EPC capturing stent showed good results. Currently, large randomized studies are conducted to evaluate the long-term safety and efficacy of this stent.
Margo Klomp; Marcel A M Beijk; Jan G P Tijssen; Robbert J de Winter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-03-09
Journal Detail:
Title:  Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions     Volume:  77     ISSN:  1522-726X     ISO Abbreviation:  Catheter Cardiovasc Interv     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-26     Completed Date:  2011-08-15     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  100884139     Medline TA:  Catheter Cardiovasc Interv     Country:  United States    
Other Details:
Languages:  eng     Pagination:  809-17     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
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MeSH Terms
Angioplasty, Balloon, Coronary / adverse effects,  instrumentation*,  mortality
Antigens, CD34 / metabolism
Coated Materials, Biocompatible*
Coronary Angiography
Coronary Restenosis / etiology,  prevention & control
Coronary Stenosis / immunology,  mortality,  pathology,  radiography,  therapy*
Diabetes Mellitus / mortality,  pathology
Endothelial Cells / immunology,  pathology*
Kaplan-Meier Estimate
Matched-Pair Analysis
Middle Aged
Myocardial Infarction / etiology,  prevention & control
Practice Guidelines as Topic
Prosthesis Design
Retrospective Studies
Risk Assessment
Risk Factors
Stem Cells / immunology,  pathology*
Thrombosis / etiology,  prevention & control
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antigens, CD34; 0/Coated Materials, Biocompatible; 0/Metals
Comment In:
Catheter Cardiovasc Interv. 2011 May 1;77(6):818-9   [PMID:  21520383 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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