Document Detail


One-year effects of vitamin D and calcium supplementation on chronic periodontitis.
MedLine Citation:
PMID:  20809866     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: A previous study reported by this group found that patients in periodontal maintenance programs taking vitamin D and calcium supplementation had a trend for better periodontal health compared to patients not taking supplementation. The objective of the present study is to determine, for the same cohort of subjects, whether such differences persist over a 1-year period.
METHODS: Fifty-one patients enrolled in maintenance programs from two dental clinics were recruited. Of these, 23 were taking vitamin D (≥400 IU/day) and calcium (≥1,000 mg/day) supplementation, and 28 were not. All subjects had at least two interproximal sites with ≥3 mm clinical attachment loss. For mandibular-posterior teeth, gingival index, plaque index, probing depth, attachment loss, bleeding on probing, calculus index, and furcation involvement were evaluated. Photostimulable-phosphor, posterior bitewing radiographs were taken to assess alveolar bone. Daily vitamin D and calcium intakes were estimated by nutritional analysis. Data were collected at baseline, 6 months, and 12 months.
RESULTS: Total daily calcium and vitamin D intakes were 1,769 mg (95% confidence interval, 1,606 to 1,933) and 1,049 IU (781 to 1,317) in the taker group, and 642 mg (505 to 779) and 156 IU (117 to 195) in the non-taker group, respectively (P <0.001 for both). Clinical parameters of periodontal health improved with time in both groups (P <0.001). When clinical measures were considered collectively, the differences between supplement takers and non-takers had the following P values: baseline (P = 0.061); 6 months (P = 0.049); and 12 months (P = 0.114). After adjusting for covariates, the P values for the effect of supplementation were as follows: baseline (P = 0.028); 6 months (P = 0.034); and 12 months (P = 0.058).
CONCLUSIONS: Calcium and vitamin D supplementation (≤1,000 IU/day) had a modest positive effect on periodontal health, and consistent dental care improved clinical parameters of periodontal disease regardless of such supplements. Our findings support the possibility that vitamin D may positively impact periodontal health and confirm the need for randomized clinical trials on the effects of vitamin D on periodontitis.
Authors:
M Nathalia Garcia; Charles F Hildebolt; D Douglas Miley; Debra A Dixon; Rex A Couture; Catherine L Anderson Spearie; Eric M Langenwalter; William D Shannon; Elena Deych; Cheryl Mueller; Roberto Civitelli
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural     Date:  2010-09-01
Journal Detail:
Title:  Journal of periodontology     Volume:  82     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-29     Completed Date:  2011-06-06     Revised Date:  2013-05-14    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-32     Citation Subset:  D; IM    
Affiliation:
Graduate Periodontics, Saint Louis University Center for Advanced Dental Education, St. Louis, MO 63104, USA. garciamn@slu.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alveolar Bone Loss / classification,  prevention & control
Calcium, Dietary / administration & dosage,  analysis,  therapeutic use*
Chronic Periodontitis / classification,  prevention & control*
Cohort Studies
Dental Calculus / classification
Dental Plaque Index
Dental Prophylaxis
Dental Scaling
Dietary Supplements*
Female
Follow-Up Studies
Food Analysis
Furcation Defects / classification,  prevention & control
Gingival Hemorrhage / classification,  prevention & control
Humans
Male
Middle Aged
Oral Hygiene
Periodontal Attachment Loss / classification,  prevention & control
Periodontal Index
Periodontal Pocket / classification,  prevention & control
Prospective Studies
Radiography, Bitewing
Root Planing
Vitamin D / administration & dosage,  analysis,  therapeutic use*
Vitamins / administration & dosage,  analysis,  therapeutic use*
Grant Support
ID/Acronym/Agency:
P30 AR057235/AR/NIAMS NIH HHS; R21 DE016918/DE/NIDCR NIH HHS; R21 DE016918/DE/NIDCR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1 RR024992/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Calcium, Dietary; 0/Vitamins; 1406-16-2/Vitamin D
Comments/Corrections
Comment In:
J Periodontol. 2011 Jun;82(6):806; author reply 806-8   [PMID:  21635160 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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