| One week pulse therapy with itraconazole (200 mg day-1) for onychomycosis. Evaluation of treatment results according to patient background. | |
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MedLine Citation:
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PMID: 11413929 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated background factors of patients that affect the response of onycomycosis to pulse therapy with itraconazole. The regimen used in this study involved administering 200 mg of itraconazole orally on a daily basis for 1 week as one pulse, which is half of the normally recommended dose. The number of pulses was fixed at one per month, and altered in accordance with improvements in the infected nails and/or the patients' request. Patient background (n = 63) including sex, age, occupation, duration of the disease, site of lesion (fingernail, toenail), number of affected nails, clinical types, severity of thickening, presence or absence of pathogens, the presence or absence of underlying diseases such as adult onset diseases, turbidity of the target nails before therapy and the number and duration of pulses was investigated. The efficacy of the therapy was evaluated after 12 months. A complete cure was judged to have taken place if an entirely healthy nail plate re-grew in place of the diseased nail, whereas lack of success was defined as the persistence of lesions beyond the designated time period. The average number and duration of pulses were 4.7 +/- 3.2 times over 5.6 +/- 4.3 months, respectively. The rate of complete cure was 62%. Factors in the patients' background that were judged to have an influence on treatment results were the relative duration of the disease, the number of affected nails, and severity of thickening. With regard to the efficacy of the therapy in terms of the number and duration of pulses, 78% of 23 patients who were given pulse therapy two to six times during a course of 2 to 6 months achieved total cure. |
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Authors:
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M Hiruma; A Matsushita; M Kobayashi; H Ogawa |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Mycoses Volume: 44 ISSN: 0933-7407 ISO Abbreviation: Mycoses Publication Date: 2001 May |
Date Detail:
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Created Date: 2001-06-20 Completed Date: 2001-08-09 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 8805008 Medline TA: Mycoses Country: Germany |
Other Details:
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Languages: eng Pagination: 87-93 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo, 113-8421, Japan. m-hiruma@cb3.so-net.ne.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Adolescent Adult Aged Aged, 80 and over Antifungal Agents / administration & dosage, therapeutic use* Child Child, Preschool Female Follow-Up Studies Humans Itraconazole / administration & dosage, therapeutic use* Longitudinal Studies Male Middle Aged Occupations Onychomycosis / drug therapy*, pathology Pulse Therapy, Drug Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antifungal Agents; 84625-61-6/Itraconazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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