Document Detail


One or two day mifepristone-misoprostol interval for second trimester abortion.
MedLine Citation:
PMID:  17712654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
METHODS: A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h. RESULTS: The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98% within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001). CONCLUSION: The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care.
Authors:
Lisbeth Nilas; Marianne Glavind-Kristensen; Thomas Vejborg; Ulla Breth Knudsen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  86     ISSN:  0001-6349     ISO Abbreviation:  Acta Obstet Gynecol Scand     Publication Date:  2007  
Date Detail:
Created Date:  2007-08-22     Completed Date:  2007-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  1117-21     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Hvidovre Hospital, Denmark. lisbeth.nilas@hh.hosp.dk
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MeSH Terms
Descriptor/Qualifier:
Abortifacient Agents, Nonsteroidal / administration & dosage,  pharmacology*
Abortifacient Agents, Steroidal / administration & dosage,  pharmacology*
Abortion, Induced / methods*
Administration, Intravaginal
Administration, Oral
Adult
Cohort Studies
Female
Gestational Age
Gravidity
Humans
Mifepristone / administration & dosage,  pharmacology*
Misoprostol / administration & dosage,  pharmacology*
Parity
Pregnancy
Pregnancy Trimester, Second
Retrospective Studies
Time Factors
Treatment Outcome
Chemical
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 0/Abortifacient Agents, Steroidal; 59122-46-2/Misoprostol; 84371-65-3/Mifepristone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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