| One or two day mifepristone-misoprostol interval for second trimester abortion. | |
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MedLine Citation:
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PMID: 17712654 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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METHODS: A retrospective 2-year cohort study of 127 women, with gestation between 13 and 24 weeks and a live fetus, seeking induced abortion. The aim was to compare the effect of a 1-day and a 2-day interval between oral mifepristone (200 mg) and vaginal misoprostol (400 microg) every 3 h. RESULTS: The time to fetal expulsion was longer (9.8 versus 7.5 h; p<0.01) in the 1-day than in the 2-day group, but the median number of applications were identical and abortion occurred in 98% within 24 h in both groups The time to abortion was longer in women with a gestation of 17-22 weeks compared to women with lower gestation (10.2 versus 6.8 h; p<0.001), and longer in nulliparae than in parous women (10.0 versus 6.7 h; p<0.001). CONCLUSION: The combined regimen of mifepristone and misoprostol is effective in the second trimester, and the interval between the drugs can be reduced allowing individualised patient care. |
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Authors:
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Lisbeth Nilas; Marianne Glavind-Kristensen; Thomas Vejborg; Ulla Breth Knudsen |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: 86 ISSN: 0001-6349 ISO Abbreviation: Acta Obstet Gynecol Scand Publication Date: 2007 |
Date Detail:
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Created Date: 2007-08-22 Completed Date: 2007-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 1117-21 Citation Subset: IM |
Affiliation:
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Department of Obstetrics and Gynecology, Hvidovre Hospital, Denmark. lisbeth.nilas@hh.hosp.dk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortifacient Agents, Nonsteroidal
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administration & dosage,
pharmacology* Abortifacient Agents, Steroidal / administration & dosage, pharmacology* Abortion, Induced / methods* Administration, Intravaginal Administration, Oral Adult Cohort Studies Female Gestational Age Gravidity Humans Mifepristone / administration & dosage, pharmacology* Misoprostol / administration & dosage, pharmacology* Parity Pregnancy Pregnancy Trimester, Second Retrospective Studies Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Abortifacient Agents, Nonsteroidal; 0/Abortifacient Agents, Steroidal; 59122-46-2/Misoprostol; 84371-65-3/Mifepristone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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