Document Detail

One-stop clinic for assessment of risk of chromosomal defects at 12 weeks of gestation.
MedLine Citation:
PMID:  12422904     Owner:  NLM     Status:  MEDLINE    
Prenatal diagnosis of trisomy 21 requires an invasive test in women considered to be at high risk after screening. At present, there are four screening tests. For a 5% false-positive rate, the sensitivities are approximately 30% for maternal age alone, 60-70% for maternal age and second-trimester maternal serum biochemical testing, 75% for maternal age and first-trimester fetal nuchal translucency (NT) scanning, and 90% for maternal age with fetal NT and maternal serum free beta-human chorionic gonadotropin (beta-hCG) and pregnancy-associated plasma protein-A (PAPP-A) at 11-14 weeks. This article examines the methodology of first-trimester screening and summarizes the results from all studies reporting on the implementation of this method.
K H Nicolaides; R Bindra; V Heath; S Cicero
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  12     ISSN:  1476-7058     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2002 Jul 
Date Detail:
Created Date:  2002-11-08     Completed Date:  2003-01-21     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  9-18     Citation Subset:  IM    
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, King's College London, UK.
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MeSH Terms
Chorionic Gonadotropin, beta Subunit, Human / blood
Down Syndrome / diagnosis*
False Positive Reactions
Gestational Age
Maternal Age
Neck / embryology,  ultrasonography
Predictive Value of Tests
Pregnancy Trimester, First
Pregnancy, High-Risk
Pregnancy-Associated Plasma Protein-A / metabolism
Prenatal Diagnosis* / methods,  standards
Sensitivity and Specificity
Reg. No./Substance:
0/Chorionic Gonadotropin, beta Subunit, Human; EC 3.4.24.-/Pregnancy-Associated Plasma Protein-A

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