Document Detail

One-shot, low-dosage intratympanic gentamicin for Ménière's disease: Clinical, posturographic and vestibular test findings.
MedLine Citation:
PMID:  24800045     Owner:  NLM     Status:  PubMed-not-MEDLINE    
BACKGROUND: Ménière's disease has been remained as a difficult therapeutic challenge. The present study aimed to determine the effects of one-shot low-dosage intratympanic gentamicin on vertigo control, auditory outcomes and findings of computerized dynamic posturography and vestibular evoked myogenic potentials in patients with unilateral Ménière's disease.
METHODS: In a prospective clinical study, 30 patients with unilateral Ménière's disease were treated with one-shot intratympanic injection of 20 milligrams gentamicin. Main outcome measures included clinical, audiometric, postural and vestibular outcomes evaluated 1 and 9 months after the treatment.
RESULTS: Mean vertigo attacks frequency, pure tone average threshold and functional level scale significantly decreased after the treatment (P < 0.05). Effective vertigo control (class A and B) obtained in 95.8% of the patients. In total, 75% of patients reported decrease in both aural fullness and tinnitus. Vestibular evoked myogenic potentials became absent in all the patients but four of them. Posturographic scores were improved after the treatment.
CONCLUSION: One-shot low-dosage gentamicin was effective in controlling vertigo attacks in Ménière's disease and has useful effects on aural fullness and tinnitus of patients as well. Postural and vestibular tests only have adjunctive role for monitoring therapeutic responses in intratympanic gentamicin-therapy.
Ahmad Daneshi; Hesam Jahandideh; Seyed Behzad Pousti; Shabahang Mohammadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Iranian journal of neurology     Volume:  13     ISSN:  2008-384X     ISO Abbreviation:  Iran J Neurol     Publication Date:  2014  
Date Detail:
Created Date:  2014-05-06     Completed Date:  2014-05-06     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  101589458     Medline TA:  Iran J Neurol     Country:  Iran    
Other Details:
Languages:  eng     Pagination:  33-9     Citation Subset:  -    
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