| One-pot synthesis of brush-like polymers via integrated ring-opening metathesis polymerization and polymerization of amino acid N-carboxyanhydrides. | |
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MedLine Citation:
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PMID: 19725499 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report here the integration of ring-opening metathesis polymerization (ROMP) and ring-opening polymerization of the amino acid N-carboxyanhydride (NCA) to allow facile synthesis of brush-like polymers containing polypeptide as the brush side chains. ROMP of N-trimethylsilyl norbornenes rendered the preparation of poly(norbornene)s bearing pendant N-TMS groups. With no need to purify the resulting polymers, such macromolecular initiators could subsequently initiate controlled NCA polymerizations. Brush-like poly(norbornene)s with grafted polypeptides or block copolypeptides were readily obtained with controlled molecular weights and narrow molecular weight distributions. Because numerous ROMP and NCA monomers are widely available, this novel polymerization technique will allow easy access to numerous brush-like hybrid macromolecules with unprecedented properties and broad applications. |
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Authors:
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Hua Lu; Jing Wang; Yao Lin; Jianjun Cheng |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: 131 ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-23 Completed Date: 2009-12-07 Revised Date: 2011-12-21 |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: United States |
Other Details:
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Languages: eng Pagination: 13582-3 Citation Subset: IM |
Affiliation:
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Department of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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chemistry* Norbornanes / chemical synthesis* Peptides / chemical synthesis* Polymers / chemical synthesis* |
| Grant Support | |
ID/Acronym/Agency:
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1R21EB009486-01/EB/NIBIB NIH HHS; R21 CA139329-02/CA/NCI NIH HHS; R21 EB009486-01/EB/NIBIB NIH HHS; R21 EB009486-02/EB/NIBIB NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Norbornanes; 0/Peptides; 0/Polymers |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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