Document Detail

One-lung versus two-lung ventilation in the closed-chest anesthetized dog: a comparison of cardiopulmonary parameters.
MedLine Citation:
PMID:  10917287     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate cardiopulmonary effects of one-lung ventilation (OLV) versus two-lung ventilation (TLV) in closed-chest anesthetized dogs.
STUDY DESIGN: Controlled, randomized experiment.
ANIMALS: Fourteen, 2- to 7-year-old adult dogs, weighing 23 +/- 6 kg.
METHODS: The dogs were anesthetized with acepromazine, morphine, thiopental, and halothane in oxygen, ventilated, and paralyzed with vecuronium. Tidal volume was 10 mL/kg. Respiratory rate was set to maintain end-tidal CO2 (ETCO2) at 40 +/- 2 mm Hg before instrumentation then not changed. The left bronchus of 7 dogs was obstructed with a Univent bronchial blocker (Fuji Systems Corp, Tokyo, Japan). Blood gas analysis and hemodynamic measurements were taken at predetermined intervals for 1 hour in the TLV group and at baseline and following bronchial obstruction in the OLV group.
RESULTS: Shunt fraction was not significantly different between groups, but in OLV shunt increased from baseline at 5 minutes. Arterial oxygen (PaO2) decreased after baseline in OLV compared with TLV. Arterial carbon dioxide (PaCO2) increased with OLV and decreased with TLV. In OLV, systemic vascular resistance was variable and decreased compared with TLV. Cardiac index increased over time in both groups but was not affected by treatment. Heart rate, mean arterial pressure, and diastolic arterial pressure increased with OLV compared with TLV but did not change over time.
CONCLUSION: This study shows that OLV statistically decreases oxygen tension and transiently increases shunt fraction, but with 100% O2 it appears to be a feasible procedure with minimal cardiopulmonary side effects in healthy dogs.
CLINICAL RELEVANCE: OLV is a feasible procedure in anesthetized dogs to better facilitate thoracic procedures such as bronchopleural fistula repair and thoracoscopy.
S L Cantwell; T Duke; P J Walsh; A M Remedios; D Walker; J G Ferguson
Related Documents :
15449067 - Integrated characterization of the human chemoreflex system controlling ventilation, us...
3924377 - End-tidal carbon dioxide tension and temperature changes after coronary artery bypass s...
582627 - Inhibition of the activity of the respiratory and vasomotor centers by centrally admini...
8968187 - Intraabdominal carbon dioxide insufflation in the pregnant ewe. uterine blood flow, int...
17679677 - Respiratory countermaneuvers in autonomic failure.
18346087 - The lifetimes of pharaonis phoborhodopsin signaling states depend on the rates of proto...
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Veterinary surgery : VS     Volume:  29     ISSN:  0161-3499     ISO Abbreviation:  Vet Surg     Publication Date:    2000 Jul-Aug
Date Detail:
Created Date:  2000-09-14     Completed Date:  2000-09-14     Revised Date:  2011-04-25    
Medline Journal Info:
Nlm Unique ID:  8113214     Medline TA:  Vet Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  365-73     Citation Subset:  IM    
Department of Veterinary Anesthesia, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Anesthesia, General / veterinary*
Dogs / physiology*,  surgery*
Intubation, Intratracheal / veterinary
Respiration, Artificial / veterinary*
Thoracic Surgical Procedures / veterinary*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  In vitro biomechanical properties of 2 compression fixation methods for midbody proximal sesamoid bo...
Next Document:  Pathogenesis of Hirschsprung's disease.