| One-dimensional ROESY experiments with full sensitivity and reliable cross-peak integration when applied to natural products. | |
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MedLine Citation:
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PMID: 19639988 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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The three-dimensional structure determination of a medium-size natural product often requires recording time-consuming 2D ROESY spectra. When the amount of sample available is limited, a series of suitable 1D selective ROESY experiments provide the same information using much less experimental time. The setup and the choice of 1D selective ROESY experiments are critical to obtain reliable results. Often, organic and natural products chemists overlook these aspects and do not make the most effective possible use of existing ROESY experiments. We propose a 1D selective ROESY experiment tailor-made for investigating the structure of natural products. The experiment has been tested on a sample of cyclosporine, and analyses of the spectra demonstrate that the experiment provides clean spectra, allowing reliable cross-peak integration while maintaining high sensitivity. In addition, the experiment does not need a sample-specific setup and can be used as it is starting from standard parameters set by inexperienced users as well as under automated conditions. |
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Authors:
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Julien Furrer |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of natural products Volume: 72 ISSN: 1520-6025 ISO Abbreviation: J. Nat. Prod. Publication Date: 2009 Aug |
Date Detail:
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Created Date: 2009-08-28 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906882 Medline TA: J Nat Prod Country: United States |
Other Details:
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Languages: eng Pagination: 1437-41 Citation Subset: IM |
Affiliation:
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Service Analytique Facultaire, Institut de Chimie, Universite de Neuchatel, Avenue de Bellevaux 51, Case Postale 158, CH-2009 Neuchatel, Switzerland. julien.furrer@unine.ch |
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