| One-year treatment with rosuvastatin reduces intima-media thickness in 45 hypercholesterolemic subjects with asymptomatic carotid artery disease. | |
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MedLine Citation:
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PMID: 20110750 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of our study was to evaluate whether a reduction in CIMT could be seen with 1-year treatment with rosuvastatin (10 mg/day). METHODS AND RESULTS: Forty-five patients with hypercholesterolemia and asymptomatic carotid atherosclerosis on baseline carotid ultrasound investigation (CUI) were examined with repeat CUI after 1 year of treatment (rosuvastatin 10 mg/day). Demographic and lifestyle data were collected. A physical examination was performed, and fasting venous blood samples were obtained. Total cholesterol, low-density lipoprotein cholesterol and triglycerides decreased significantly (p < 0.001), while high-density lipoprotein cholesterol increased significantly (p < 0.001) during the intervention. The mean decreases in the IMT of the right and left common carotid arteries (CCAs) were 0.29 and 0.26 mm, respectively (p < 0.05 for each). Age and lipid profile parameters were significant predictors of change in CIMT in linear regression analyses after adjustment for established atherosclerosis risk factors. CONCLUSIONS: One-year treatment with rosuvastatin in hypercholesterolemic adults with evidenceof subclinical atherosclerosis significantly reduced the CIMT of both CCAs and improved the lipid and lipoprotein levels. |
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Authors:
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Graziano Riccioni; Nicola Vitulano; Barbara Mancini; Alessandra Zanasi; Nicolantonio D'Orazio |
Publication Detail:
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Type: Comparative Study; Journal Article; Randomized Controlled Trial Date: 2010-01-21 |
Journal Detail:
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Title: Pharmacology Volume: 85 ISSN: 1423-0313 ISO Abbreviation: Pharmacology Publication Date: 2010 |
Date Detail:
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Created Date: 2010-02-17 Completed Date: 2010-10-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0152016 Medline TA: Pharmacology Country: Switzerland |
Other Details:
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Languages: eng Pagination: 63-7 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 S. Karger AG, Basel. |
Affiliation:
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Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Italy. griccioni @ hotmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Atherosclerosis
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drug therapy,
pathology Carotid Artery Diseases / drug therapy*, pathology* Cross-Sectional Studies Female Fluorobenzenes / administration & dosage* Humans Hypercholesterolemia / drug therapy*, pathology* Male Middle Aged Prospective Studies Pyrimidines / administration & dosage* Sulfonamides / administration & dosage* Time Factors Tunica Intima / drug effects, pathology* Tunica Media / drug effects, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Fluorobenzenes; 0/Pyrimidines; 0/Sulfonamides; 287714-41-4/rosuvastatin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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