Document Detail


One-year treatment with rosuvastatin reduces intima-media thickness in 45 hypercholesterolemic subjects with asymptomatic carotid artery disease.
MedLine Citation:
PMID:  20110750     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: An increase in carotid intima-media thickness (CIMT) represents an early phase of the atherosclerotic process. The aim of our study was to evaluate whether a reduction in CIMT could be seen with 1-year treatment with rosuvastatin (10 mg/day). METHODS AND RESULTS: Forty-five patients with hypercholesterolemia and asymptomatic carotid atherosclerosis on baseline carotid ultrasound investigation (CUI) were examined with repeat CUI after 1 year of treatment (rosuvastatin 10 mg/day). Demographic and lifestyle data were collected. A physical examination was performed, and fasting venous blood samples were obtained. Total cholesterol, low-density lipoprotein cholesterol and triglycerides decreased significantly (p < 0.001), while high-density lipoprotein cholesterol increased significantly (p < 0.001) during the intervention. The mean decreases in the IMT of the right and left common carotid arteries (CCAs) were 0.29 and 0.26 mm, respectively (p < 0.05 for each). Age and lipid profile parameters were significant predictors of change in CIMT in linear regression analyses after adjustment for established atherosclerosis risk factors. CONCLUSIONS: One-year treatment with rosuvastatin in hypercholesterolemic adults with evidenceof subclinical atherosclerosis significantly reduced the CIMT of both CCAs and improved the lipid and lipoprotein levels.
Authors:
Graziano Riccioni; Nicola Vitulano; Barbara Mancini; Alessandra Zanasi; Nicolantonio D'Orazio
Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial     Date:  2010-01-21
Journal Detail:
Title:  Pharmacology     Volume:  85     ISSN:  1423-0313     ISO Abbreviation:  Pharmacology     Publication Date:  2010  
Date Detail:
Created Date:  2010-02-17     Completed Date:  2010-10-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0152016     Medline TA:  Pharmacology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  63-7     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 S. Karger AG, Basel.
Affiliation:
Cardiology Unit, San Camillo de Lellis Hospital, Manfredonia, Italy. griccioni @ hotmail.com
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MeSH Terms
Descriptor/Qualifier:
Atherosclerosis / drug therapy,  pathology
Carotid Artery Diseases / drug therapy*,  pathology*
Cross-Sectional Studies
Female
Fluorobenzenes / administration & dosage*
Humans
Hypercholesterolemia / drug therapy*,  pathology*
Male
Middle Aged
Prospective Studies
Pyrimidines / administration & dosage*
Sulfonamides / administration & dosage*
Time Factors
Tunica Intima / drug effects,  pathology*
Tunica Media / drug effects,  pathology*
Chemical
Reg. No./Substance:
0/Fluorobenzenes; 0/Pyrimidines; 0/Sulfonamides; 287714-41-4/rosuvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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