| One-year serum albumin is an independent predictor of outcomes in kidney transplant recipients. | |
| | |
MedLine Citation:
|
PMID: 20537920 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This research study was conducted to investigate whether serum albumin levels predict allograft/patient outcomes in the new era of transplant medicine and immunology. METHODS: The association of 1-year post-transplant serum albumin, and patient and graft outcomes was retrospectively analyzed in 500 kidney transplant recipients between 1998 and 2005. Albumin was used as a categorical and a continuous variable in univariate and multivariate Cox regression and Kaplan-Meier survival analyses. RESULTS: The average (±SE) age at transplant was 47 ± 12 years. Patients were followed up for 63.4 ± 28 months after transplant. There were 56 graft losses and 38 patient deaths. In univariate analysis, the following variables were associated with the composite endpoint of patient death or allograft loss: 1-year serum albumin (hazard ratio [HR] = 0.52, P = .0009), 1-year serum albumin <4.0 g/dL (HR = 1.81, P = .02), 1-year serum creatinine (HR = 3.55, P < .00001), angiotensin converting enzyme inhibitors or angiotensin receptor blockers use (HR = 1.61, P = .03), a history of previous transplant (HR = 1.54, P = .04), months of dialysis before transplant (HR = 1.01, P = .00003), type of transplant (deceased donor HR = 1.64, P = .02), and acute rejection (HR = 1.52, P = .0000003). Of these, multivariable Cox regression analyses retained 1-year serum albumin (HR = 1.4, P < .0001), serum creatinine (HR = 2.7, P < .0001), and acute rejection (HR = 1.7, P = .02) as significant predictors of patient/graft loss. CONCLUSION: One-year serum albumin is an independent predictor of poor outcomes in the contemporary era of transplant medicine and immunosuppression. Further studies are needed to separate the role of this biomarker in inflammation and nutrition in kidney transplant recipients. |
| | |
Authors:
|
Rebecca Dahlberg; Brenda Muth; Milagros Samaniego; R Michael Hofmann; John Pirsch; Arjang Djamali |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-26 |
Journal Detail:
|
Title: Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation Volume: 20 ISSN: 1532-8503 ISO Abbreviation: J Ren Nutr Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-19 Completed Date: 2011-01-27 Revised Date: 2013-05-29 |
Medline Journal Info:
|
Nlm Unique ID: 9112938 Medline TA: J Ren Nutr Country: United States |
Other Details:
|
Languages: eng Pagination: 392-7 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 National Kidney Foundation, Inc. Published by Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Medicine, University of Wisconsin Madison SMPH, Madison, Wisconsin 53792, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Angiotensin Receptor Antagonists / blood Angiotensin-Converting Enzyme Inhibitors / blood Biological Markers Creatinine / blood Female Graft Rejection / immunology, mortality* Graft Survival* Humans Kaplan-Meier Estimate Kidney Failure, Chronic / therapy* Kidney Transplantation / immunology*, mortality Male Middle Aged Regression Analysis Retrospective Studies Serum Albumin / analysis* Transplantation, Homologous Treatment Outcome |
| Grant Support | |
ID/Acronym/Agency:
|
DK 070243-04/DK/NIDDK NIH HHS; DK067981-05/DK/NIDDK NIH HHS; K08 DK067981-05/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin Receptor Antagonists; 0/Angiotensin-Converting Enzyme Inhibitors; 0/Biological Markers; 0/Serum Albumin; 60-27-5/Creatinine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Vitamin D deficiency in dialysis patients: effect of dialysis modality and implications on outcome.
Next Document: Spinal analgesia in cardiac surgery.