| One-Year Progression of Moderate Asymptomatic Carotid Stenosis Predicts the Risk of Vascular Events. | |
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MedLine Citation:
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PMID: 23287778 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND AND PURPOSE: This study aimed at evaluating whether ultrasound monitoring of moderate asymptomatic carotid stenosis may help in identifying subjects at high risk for vascular events. METHODS: We included 523 subjects with unilateral asymptomatic carotid stenosis of 50% to 69%. Follow-up carotid ultrasound was performed within 12 months from inclusion to detect the frequency and degree of stenosis progression. Subjects were prospectively evaluated for a median period of 42 months (interquartile range, 38-45) after a second ultrasound evaluation. Outcome measures were any stroke and transient ischemic attack, myocardial infarction, and death. RESULTS: Carotid stenosis progression was associated with the occurrence of vascular events (hazard ratio, 21.57; 95% confidence interval, 11.81-39.39; P<0.001). During follow-up, 96.7% of subjects without progressive carotid stenosis remained free from vascular events. Among patients with progressive stenosis, 53.7% experienced a vascular event and 27.1% experienced an ipsilateral stroke. CONCLUSIONS: One-year moderate asymptomatic carotid stenosis progression is related to higher risk of vascular events, including ipsilateral stroke. |
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Authors:
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Simona Balestrini; Francesca Lupidi; Clotilde Balucani; Claudia Altamura; Fabrizio Vernieri; Leandro Provinciali; Mauro Silvestrini |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-3 |
Journal Detail:
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Title: Stroke; a journal of cerebral circulation Volume: - ISSN: 1524-4628 ISO Abbreviation: Stroke Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0235266 Medline TA: Stroke Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the Neurological Clinic, Marche Polytechnic University, Ancona, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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