Document Detail

Phencyclidine/schizophrenia: one view toward the past, the other to the future.
MedLine Citation:
PMID:  22390879     Owner:  NLM     Status:  MEDLINE    
The history of the chemical synthesis and animal/human pharmacology of phencyclidine is documented. From its early use as a general anesthetic, chemical model of schizophrenia, and drug of abuse, phencyclidine has had a checkered history. Research with this agent and its chemical derivatives like ketamine have provided a solid foundation for just a beginning to understanding the neuropathology of schizophrenia.
Edward F Domino; Elliot D Luby
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Publication Detail:
Type:  Historical Article; Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-05
Journal Detail:
Title:  Schizophrenia bulletin     Volume:  38     ISSN:  1745-1701     ISO Abbreviation:  Schizophr Bull     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-18     Completed Date:  2013-02-04     Revised Date:  2013-09-03    
Medline Journal Info:
Nlm Unique ID:  0236760     Medline TA:  Schizophr Bull     Country:  United States    
Other Details:
Languages:  eng     Pagination:  914-9     Citation Subset:  IM    
Department of Pharmacology, University of Michigan, Ann Arbor, MI 48109-5632, USA.
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MeSH Terms
Anesthetics / history*
Disease Models, Animal*
History, 20th Century
History, 21st Century
Neuropharmacology / history*
Phencyclidine / history*
Psychoses, Substance-Induced / history*
Schizophrenia / history*
Street Drugs / history*
Reg. No./Substance:
0/Anesthetics; 0/Street Drugs; 77-10-1/Phencyclidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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