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One-Stage Full-Mouth Disinfection as a Therapeutic Approach for Generalized Aggressive Periodontitis.
MedLine Citation:
PMID:  21091345     Owner:  NLM     Status:  Publisher    
Background: Data concerning treatment outcomes in generalized aggressive periodontitis patients (G-AgP) are limited. The aim of this study was to investigate 6-month clinical and microbiological outcomes of the one stage full-mouth disinfection (OSFMD) in the management of this group of patients. Methods: Twenty-seven patients with advanced G-AgP were included in this prospective follow-up intervention study. Clinical and microbiological parameters were collected at baseline, 3 and 6 months following the OSFMD. A patient-, tooth- and site-level analysis was carried out. Subgingival samples from moderate (4-5 mm) and deep (≥ 6 mm) pocket sites were analyzed using PCR for Aggregatibacter actinomycetemcomitans, Prevotella intermedia, Porphyromonas gingivalis, Tannerella forsythia and Treponema denticola. Results: The OSFMD resulted in significant improvement of all parameters. After 6 months, whole-mouth probing pocket depth (PPD) decreased from 4.2 ± 1.1 to 2.8 ± 0.6 mm and clinical attachment level was reduced from 4.5 ± 1.2 to 3.4 ± 1.1 mm (p< 0.001). When data were analyzed based on frequency distribution of pocket depth, the number of sites with PPD ≥ 5 mm decreased by 61% from baseline values and mean PPD reductions of 1.5 mm and 2.5 mm were noted in moderate and deep pockets. At 6 months the percentage of moderate and deep sites free of pathogens was respectively 40% and 27%. Conclusions: The OSFMD may be a viable approach to deal with severe G-AgP.
Aimetti Mario; Romano Federica; Guzzi Nicoletta; Gianfranco Carnevale
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2010-11-23
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2010 Nov 
Date Detail:
Created Date:  2010-11-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Department of Periodontology, Dental School, University of Torino, Torino, Italy.
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