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One Bout of Exercise Alters Free-Living Postprandial Glycemia in Type 2 Diabetes.
MedLine Citation:
PMID:  23872939     Owner:  NLM     Status:  Publisher    
PURPOSE: Elevated postprandial glycemic excursions (PPG) are significant risk factors for cardiovascular disease in type 2 diabetes patients. Here we tested if and for how many meals a single bout of exercise would reduce PPG responses to subsequent meals in type 2 diabetes (T2D) patients using continuous glucose monitors (CGMS).
METHODS: We recruited 9 sedentary (<30 minutes/week of exercise) individuals with T2D (BMI: 36.0 ± 1.1 kg/m; age 60.3 ± 1.0 years; HbA1c: 6.3 ± 0.2 %). The subjects consumed a eucaloric diet (51% carbohydrate, 31% fat, 18% protein) consisting of 3 meals, identical in composition, over a 2-day period while wearing CGMS in two different conditions (exercise (EX; one 60 minute bout at 60-75% of heart rate reserve performed prior to breakfast) vs. a sedentary (SED) condition). We quantified 24-h average glucose, PPG-AUC (4 h glucose AUC following meals) and PPG-2 h (2 hour post-prandial glucose).
RESULTS: EX significantly reduced average [glucose] during the first 24 hour period (p=0.03). EX caused a reduction in PPG-AUC (p=0.02) for all of the meals over the two days (main effect between conditions). Comparison between the EX and SED conditions at each meal revealed that EX reduced PPG-AUC following the second meal of day 1 (lunch) (p=0.04). PPG-2 h was not significantly different between EX and SED.
CONCLUSION: Although a single EX bout does lower 24-h average [glucose], it only significantly lowered PPG-AUC at the second meal following the bout suggesting that daily exercise may be needed to most effectively improve PPG at the advent of exercise training in T2D patients.
Douglas J Oberlin; Catherine R Mikus; Monica L Kearney; Pamela S Hinton; Camila Manrique; Heather J Leidy; Jill A Kanaley; R Scott Rector; John P Thyfault
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-7-18
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  -     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2013 Jul 
Date Detail:
Created Date:  2013-7-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Departments of 1Nutrition and Exercise Physiology, and Internal Medicine, 2Division of Gastroenterology and Hepatology, 3Division of Endocrinology, University of Missouri, Columbia, MO; 4Harry S Truman Memorial VA Hospital, Columbia, MO; 5Division of Cardiology, Duke University Medical Center, Durham, NC.
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