Document Detail

Ondine's curse in association with diabetes insipidus following transient vertebrobasilar ischemia.
MedLine Citation:
PMID:  10536907     Owner:  NLM     Status:  MEDLINE    
Ischemic lesions of the brainstem can lead to complex neurologic deficits. Failure of the automatic control of ventilation (Ondine's curse syndrome) is a possible but rare syndrome following localized brainstem dysfunction. We report on a 49-year-old man with intermittent bradycardia, cranial nerves' dysfunctions and a slight right-sided hemiparesis. An acute brainstem ischemia was diagnosed and treated immediately with high-dose heparin. Cerebral angiography revealed a proximal occlusion of the left vertebral artery but a normal right vertebral artery and a hyperplastic right posterior inferior cerebellar artery. Cranial Computed Tomography and MRI scan demonstrated multiple ischemic lesions in the posterior circulation. During a 4-week treatment course the patient underwent six episodes of acute severe hypoxia and hypercapnia requiring orotracheal intubation twice and manual ventilation by air mask over a few minutes for four times after a tracheostomy had been performed. Twice a short-term episode of hypothalamic Diabetes insipidus was observed following hypoventilation. We conclude that both Ondine's curse syndrome and diabetes insipidus were due to transient vertebrobasilar ischemia.
J Kraus; J G Heckmann; A Druschky; F Erbguth; B Neundorfer
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Clinical neurology and neurosurgery     Volume:  101     ISSN:  0303-8467     ISO Abbreviation:  Clin Neurol Neurosurg     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-11-12     Completed Date:  1999-11-12     Revised Date:  2009-10-14    
Medline Journal Info:
Nlm Unique ID:  7502039     Medline TA:  Clin Neurol Neurosurg     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  196-8     Citation Subset:  IM    
Department of Neurology, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
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MeSH Terms
Brain Stem Infarctions / complications*,  diagnosis
Cerebral Angiography
Diabetes Insipidus / etiology*
Ischemic Attack, Transient / complications*,  diagnosis
Middle Aged
Sleep Apnea, Central / etiology*
Treatment Outcome
Vertebral Artery / pathology
Vertebrobasilar Insufficiency / complications*,  diagnosis*,  therapy

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