Document Detail

Ondansetron vs. metoclopramide for the prevention of nausea and vomiting after gynecologic surgery.
MedLine Citation:
PMID:  18672630     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Postoperative nausea and vomiting (PONV) remains a very troublesome concomitant phenomenon after general anesthesia. The present study was designed to compare the efficacy and safety of ondansetron with metoclopramide for prophylaxis of PONV in patients undergoing major gynecological surgery. MATERIAL AND METHOD: A prospective, randomized, double-blind, 382 female patients received either ondansetron 4 mg or metoclopramide 10 mg intravenous administration immediately before the induction of anesthesia. A standard general anesthetic technique was employed throughout. Nausea, vomiting, and safety assessments were performed continuously during the 24 h postoperative period. RESULTS: Of the 380 patients evaluated, significantly fewer ondansetron 4 mg treated patients (89/189; 47%) experienced postoperative nausea and/or vomiting compared with metoclopramide treated patients (115/ 191; 60%) during the study period (p = 0.007, 95% CI: 1.07, 1.66). Postoperative adverse events were not significantly different between the groups. CONCLUSION: Prophylactic use of ondansetron is more effective than metoclopramide for preventing PONV in patients undergoing major gynecological surgery.
Banjong Krobbuaban; Samrong Pitakpol; Siriwan Diregpoke
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Journal of the Medical Association of Thailand = Chotmaihet thangphaet     Volume:  91     ISSN:  0125-2208     ISO Abbreviation:  J Med Assoc Thai     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-08-04     Completed Date:  2008-09-10     Revised Date:  2008-10-10    
Medline Journal Info:
Nlm Unique ID:  7507216     Medline TA:  J Med Assoc Thai     Country:  Thailand    
Other Details:
Languages:  eng     Pagination:  669-74     Citation Subset:  IM    
Division of Anesthesiology, Chaiyaphum Hospital, Chaiyaphum, Thailand.
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MeSH Terms
Antiemetics / administration & dosage,  therapeutic use*
Double-Blind Method
Gynecologic Surgical Procedures / adverse effects*
Metoclopramide / administration & dosage,  therapeutic use*
Middle Aged
Nausea / etiology,  prevention & control*
Ondansetron / administration & dosage,  therapeutic use*
Postoperative Complications / prevention & control*
Prospective Studies
Vomiting / etiology,  prevention & control*
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide; 99614-02-5/Ondansetron
Erratum In:
J Med Assoc Thai. 2008 Jul;91(7):1154
Note: dosage error in text

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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