Document Detail

Ondansetron versus dolasetron: a comparison study in the prevention of postoperative nausea and vomiting in patients undergoing gynecological procedures.
MedLine Citation:
PMID:  15098526     Owner:  NLM     Status:  MEDLINE    
The purpose of this study was to determine if 4 mg of ondansetron and 12.5 mg of dolasetron were equally effective in preventing postoperative nausea and vomiting (PONV) in patients undergoing gynecological procedures. While the overall incidence of PONV appears to be 25% to 35%, the incidence among this patient population is considerably higher. Patients were assigned to 1 of 2 antiemetic treatment groups. Patients in group 1 received 4 mg of ondansetron at the end of surgery, while patients in group 2 received 12.5 mg of dolasetron at the end of surgery. Data collection occurred perioperatively and in the 24 hours following surgery. chi 2 determined there was no statistical difference between groups related to emesis in the postanesthesia care unit (PACU), emesis in the 24 hours following surgery, and side effects. Results of this study showed there was no statistically significant difference between 4 mg of ondansetron or 12.5 mg of dolasetron when administered at the end of surgery for preventing PONV in patients undergoing gynecological procedures. Given the cost difference between these 2 antiemetics, there is a potential for significant cost savings in this high-risk patient population.
Beth A Browning; Carol A Fort; Kevan D Kemp; Manardie F Shimata; Melissa D Strube
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  AANA journal     Volume:  72     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  2004 Apr 
Date Detail:
Created Date:  2004-04-21     Completed Date:  2004-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  N    
Kaiser Permanente, Sacramento, Calif., USA.
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MeSH Terms
Antiemetics / economics,  therapeutic use*
Cost Savings
Double-Blind Method
Drug Costs / statistics & numerical data
Gynecologic Surgical Procedures / adverse effects*
Indoles / economics,  therapeutic use*
Ondansetron / economics,  therapeutic use*
Postoperative Nausea and Vomiting / drug therapy*,  epidemiology,  etiology
Prospective Studies
Quinolizines / economics,  therapeutic use*
Severity of Illness Index
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antiemetics; 0/Indoles; 0/Quinolizines; 115956-13-3/dolasetron mesylate; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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