| Ondansetron versus dolasetron: a comparison study in the prevention of postoperative nausea and vomiting in patients undergoing gynecological procedures. | |
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MedLine Citation:
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PMID: 15098526 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The purpose of this study was to determine if 4 mg of ondansetron and 12.5 mg of dolasetron were equally effective in preventing postoperative nausea and vomiting (PONV) in patients undergoing gynecological procedures. While the overall incidence of PONV appears to be 25% to 35%, the incidence among this patient population is considerably higher. Patients were assigned to 1 of 2 antiemetic treatment groups. Patients in group 1 received 4 mg of ondansetron at the end of surgery, while patients in group 2 received 12.5 mg of dolasetron at the end of surgery. Data collection occurred perioperatively and in the 24 hours following surgery. chi 2 determined there was no statistical difference between groups related to emesis in the postanesthesia care unit (PACU), emesis in the 24 hours following surgery, and side effects. Results of this study showed there was no statistically significant difference between 4 mg of ondansetron or 12.5 mg of dolasetron when administered at the end of surgery for preventing PONV in patients undergoing gynecological procedures. Given the cost difference between these 2 antiemetics, there is a potential for significant cost savings in this high-risk patient population. |
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Authors:
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Beth A Browning; Carol A Fort; Kevan D Kemp; Manardie F Shimata; Melissa D Strube |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: AANA journal Volume: 72 ISSN: 0094-6354 ISO Abbreviation: AANA J Publication Date: 2004 Apr |
Date Detail:
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Created Date: 2004-04-21 Completed Date: 2004-06-01 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0431420 Medline TA: AANA J Country: United States |
Other Details:
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Languages: eng Pagination: 129-32 Citation Subset: N |
Affiliation:
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Kaiser Permanente, Sacramento, Calif., USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antiemetics
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economics,
therapeutic use* Cost Savings Double-Blind Method Drug Costs / statistics & numerical data Female Gynecologic Surgical Procedures / adverse effects* Humans Incidence Indoles / economics, therapeutic use* Ondansetron / economics, therapeutic use* Postoperative Nausea and Vomiting / drug therapy*, epidemiology, etiology Prospective Studies Quinolizines / economics, therapeutic use* Severity of Illness Index Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antiemetics; 0/Indoles; 0/Quinolizines; 115956-13-3/dolasetron mesylate; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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