| Ondansetron and tropisetron do not prevent intraspinal morphine- and fentanyl-induced pruritus in elective cesarean delivery. | |
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MedLine Citation:
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PMID: 16430549 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Although intraspinal morphine has been shown to be effective in providing analgesia after cesarean delivery, pruritus as a side-effect remains a common cause of dissatisfaction. The role of ondansetron has been studied in preventing pruritus but the results have been contradictory. METHODS: We randomized 98 parturients undergoing elective cesarean section using combined spinal-epidural anesthesia into a double-blinded trial to receive tropisetron 5 mg (T group) or ondansetron 8 mg (O group) or placebo (NaCl group) after delivery, when intrathecal morphine 160 microg and fentanyl 15 microg were used for post-operative pain control. The patients additionally received ketoprofen 300 mg per day. Post-operative itching, nausea and vomiting, sedation and need for rescue analgesics were registered every 3 h up to 24 h, and all patients were interviewed on the first post-operative day. RESULTS: Seventy-six percent of the parturients in the placebo group, 87% in the ondansetron, and 79% in the tropisetron group had itching. The incidence of post-operative nausea and vomiting was 21%, 20% and 11% of the patients in the placebo, ondansetron and tropisetron groups, respectively. Medication for pruritus was needed by 31%, 23% and 39% of the patients in the placebo, ondansetron and tropisetron groups, respectively. In the post-operative questionnaire, the patients reported less post-operative nausea in the tropisetron group than in the placebo group (P < 0.01). CONCLUSION: Neither ondansetron nor tropisetron prevent itching caused by intrathecal morphine with fentanyl. However, tropisetron reduced post-operative nausea. |
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Authors:
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P J Sarvela; P M Halonen; A I Soikkeli; J P Kainu; K T Korttila |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Acta anaesthesiologica Scandinavica Volume: 50 ISSN: 0001-5172 ISO Abbreviation: Acta Anaesthesiol Scand Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-01-24 Completed Date: 2006-05-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370270 Medline TA: Acta Anaesthesiol Scand Country: England |
Other Details:
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Languages: eng Pagination: 239-44 Citation Subset: IM |
Affiliation:
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Department of Anaesthesia and Intensive Care, Helsinki University Central Hospital, Helsinki, Finland. Johanna.sarvela@hus.fi |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Analgesics, Opioid / administration & dosage, adverse effects Anesthesia, Epidural / methods Anesthesia, Spinal / methods Anti-Inflammatory Agents, Non-Steroidal / administration & dosage Antiemetics / administration & dosage, therapeutic use Cesarean Section / methods* Double-Blind Method Female Fentanyl / administration & dosage, adverse effects* Humans Indoles / administration & dosage, therapeutic use* Injections, Spinal / methods Ketoprofen / administration & dosage Morphine / administration & dosage, adverse effects* Ondansetron / administration & dosage, therapeutic use* Pain, Postoperative / prevention & control Postoperative Nausea and Vomiting / prevention & control Pregnancy Prospective Studies Pruritus / chemically induced* Surgical Procedures, Elective / methods Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Analgesics, Opioid; 0/Anti-Inflammatory Agents, Non-Steroidal; 0/Antiemetics; 0/Indoles; 22071-15-4/Ketoprofen; 437-38-7/Fentanyl; 57-27-2/Morphine; 89565-68-4/tropisetron; 99614-02-5/Ondansetron |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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