Document Detail

Ondansetron for prevention of postoperative nausea and vomiting following minor oral surgery: a double-blind randomized study.
MedLine Citation:
PMID:  7632207     Owner:  NLM     Status:  MEDLINE    
The efficacy and safety of ondansetron in preventing postoperative nausea and vomiting following minor oral surgery was evaluated in a prospective randomized double-blind study. Of a total of seventy-seven patients, randomly 38 had 4 mg of ondansetron and 39 had normal saline as placebo intravenously immediately prior to induction of anaesthesia. A standard general anaesthetic with thiopentone, suxamethonium, fentanyl, nitrous oxide and isoflurane was employed. Postoperatively nausea was assessed verbally and on a visual analog scale at 1, 4 and 24 hours from the time of awakening. Episodes of vomiting were recorded. Eight patients (21.1%) in the ondansetron group compared to 19 (48.7%) in the placebo group had nausea (P < 0.05) and 1 (2.6%) in the ondansetron group compared with 9 (23.1%) in the placebo group vomited (P < 0.05). Patients who vomited twice or more and the number who required a rescue antiemetic were significantly fewer in the ondansetron group (P < 0.05). Cardiovascular parameters were stable and showed no significant difference in the two groups. There were no significant adverse effects that could be directly attributable to ondansetron.
M R Rodrigo; R C Campbell; J Chow; C K Tong; E Hui; S Lueveswanij
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  22     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1994 Oct 
Date Detail:
Created Date:  1995-02-09     Completed Date:  1995-02-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  576-9     Citation Subset:  IM    
Department of Maxillofacial Surgery, Dental Faculty, University of Hong Kong.
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MeSH Terms
Anesthesia Recovery Period
Anesthesia, Inhalation
Anesthesia, Intravenous
Blood Pressure / physiology
Double-Blind Method
Injections, Intravenous
Middle Aged
Mouth / surgery*
Nausea / prevention & control*
Ondansetron / administration & dosage,  therapeutic use*
Patient Satisfaction
Postoperative Complications / prevention & control*
Prospective Studies
Pulse / physiology
Surgical Procedures, Minor
Vomiting / prevention & control*
Reg. No./Substance:
0/Placebos; 99614-02-5/Ondansetron
Comment In:
Anaesth Intensive Care. 1995 Feb;23(1):122   [PMID:  7778732 ]
Anaesth Intensive Care. 1996 Feb;24(1):116-7   [PMID:  8669631 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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