| Ondansetron for prevention of postoperative nausea and vomiting following minor oral surgery: a double-blind randomized study. | |
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MedLine Citation:
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PMID: 7632207 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy and safety of ondansetron in preventing postoperative nausea and vomiting following minor oral surgery was evaluated in a prospective randomized double-blind study. Of a total of seventy-seven patients, randomly 38 had 4 mg of ondansetron and 39 had normal saline as placebo intravenously immediately prior to induction of anaesthesia. A standard general anaesthetic with thiopentone, suxamethonium, fentanyl, nitrous oxide and isoflurane was employed. Postoperatively nausea was assessed verbally and on a visual analog scale at 1, 4 and 24 hours from the time of awakening. Episodes of vomiting were recorded. Eight patients (21.1%) in the ondansetron group compared to 19 (48.7%) in the placebo group had nausea (P < 0.05) and 1 (2.6%) in the ondansetron group compared with 9 (23.1%) in the placebo group vomited (P < 0.05). Patients who vomited twice or more and the number who required a rescue antiemetic were significantly fewer in the ondansetron group (P < 0.05). Cardiovascular parameters were stable and showed no significant difference in the two groups. There were no significant adverse effects that could be directly attributable to ondansetron. |
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Authors:
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M R Rodrigo; R C Campbell; J Chow; C K Tong; E Hui; S Lueveswanij |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 22 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 1994 Oct |
Date Detail:
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Created Date: 1995-02-09 Completed Date: 1995-02-09 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: AUSTRALIA |
Other Details:
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Languages: eng Pagination: 576-9 Citation Subset: IM |
Affiliation:
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Department of Maxillofacial Surgery, Dental Faculty, University of Hong Kong. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Anesthesia Recovery Period Anesthesia, Inhalation Anesthesia, Intravenous Blood Pressure / physiology Double-Blind Method Female Humans Injections, Intravenous Male Middle Aged Mouth / surgery* Nausea / prevention & control* Ondansetron / administration & dosage, therapeutic use* Patient Satisfaction Placebos Postoperative Complications / prevention & control* Premedication Prospective Studies Pulse / physiology Surgical Procedures, Minor Vomiting / prevention & control* |
| Chemical | |
Reg. No./Substance:
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0/Placebos; 99614-02-5/Ondansetron |
| Comments/Corrections | |
Comment In:
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Anaesth Intensive Care. 1995 Feb;23(1):122
[PMID:
7778732
]
Anaesth Intensive Care. 1996 Feb;24(1):116-7 [PMID: 8669631 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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