| Ondansetron and fluoxetine reduce sleep apnea in mice lacking monoamine oxidase A. | |
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MedLine Citation:
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PMID: 19615472 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Prospective clinical trials addressing the role of serotonin (5-HT) in sleep apnea have indicated that the 5-HT uptake inhibitor fluoxetine is beneficial to some patients with obstructive apnea, whereas the 5-HT(3) receptor antagonist ondansetron seems of little value despite its efficacy in rat and dog models of sleep apnea (central and obstructive). Here, we examined the effect of these drugs in transgenic mice lacking monoamine oxidase A (Tg8), which exhibit approximately 3-fold higher rates of central sleep apnea than their wild-type counterparts (C3H), linked to their enhanced 5-HT levels. Acute ondansetron (2 mg kg(-1), intraperitoneal), acute fluoxetine (16 mg kg(-1)) and 13-day chronic fluoxetine (1 or 16 mg kg(-1)) decreased by approximately 80% the total (spontaneous and post-sigh) apnea index in Tg8 mice during non-rapid eye movement sleep, with no statistically significant effect on apnea in C3H mice. Our study shows that both drugs reduce the frequency of apneic episodes attributable to increased monoamine levels in this model of MAOA deficiency, and suggests that both may be effective in some patients with central sleep apneas. |
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Authors:
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C Real; I Seif; J Adrien; P Escourrou |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2009-07-15 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: 168 ISSN: 1878-1519 ISO Abbreviation: Respir Physiol Neurobiol Publication Date: 2009 Sep |
Date Detail:
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Created Date: 2009-09-02 Completed Date: 2009-11-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 230-8 Citation Subset: IM |
Affiliation:
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Univ Paris-Sud, EA 3544, Sérotonine et Neuropharmacologie, Châtenay-Malabry cedex, France. caroline.prenat@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Disease Models, Animal Dose-Response Relationship, Drug Fluoxetine / pharmacology* Mice Mice, Inbred C3H Mice, Knockout Monoamine Oxidase / deficiency* Ondansetron / pharmacology* Plethysmography, Whole Body / methods Respiratory Mechanics / drug effects* Serotonin Antagonists / pharmacology* Serotonin Uptake Inhibitors / pharmacology* Sleep Apnea Syndromes / drug therapy, genetics* Wakefulness / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Serotonin Antagonists; 0/Serotonin Uptake Inhibitors; 54910-89-3/Fluoxetine; 99614-02-5/Ondansetron; EC 1.4.3.4/Monoamine Oxidase |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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