Document Detail

Ondansetron decreases emesis after tonsillectomy in children.
MedLine Citation:
PMID:  8109763     Owner:  NLM     Status:  MEDLINE    
We performed a double-blind, randomized, placebo-controlled trial to investigate the efficacy and safety of ondansetron in preventing vomiting after tonsillectomy with or without adenoidectomy in children. Sixty children were premedicated with 0.5 mg/kg of oral midazolam and underwent inhaled induction and maintenance of anesthesia with halothane and nitrous oxide. Intravenous morphine 0.075 mg/kg, vecuronium 0.1 mg/kg, and either ondansetron 0.15 mg/kg (maximum = 8 mg), or saline placebo were administered after intravenous catheter placement. All episodes of postoperative vomiting on the day of surgery and the following day were recorded. There were no significant differences between the two groups with regard to age, weight, sex, time to endotracheal intubation, duration of surgery, duration of anesthesia, or number of patients having adenoidectomy. More patients in the ondansetron group received dexamethasone as part of the surgeon's routine protocol (P = 0.03). Twenty-three children (77%) who received ondansetron were emesis-free as opposed to only eight (27%) in the placebo group (P < 0.001). This was especially evident in the number of children who had two or more episodes of vomiting; 17 children (57%) who received placebo had two or more episodes of vomiting as opposed to only two children (7%) who received ondansetron. The incidence of emesis on the day after the surgery did not differ between the two groups. Three children who received ondansetron and one who received placebo complained of abdominal cramping on the night of the surgery. There were no other complaints or complications. Analysis of the 51 children who did not receive dexamethasone revealed similar results.(ABSTRACT TRUNCATED AT 250 WORDS)
R S Litman; C L Wu; F A Catanzaro
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesia and analgesia     Volume:  78     ISSN:  0003-2999     ISO Abbreviation:  Anesth. Analg.     Publication Date:  1994 Mar 
Date Detail:
Created Date:  1994-03-24     Completed Date:  1994-03-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1310650     Medline TA:  Anesth Analg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  478-81     Citation Subset:  AIM; IM    
Department of Anesthesiology, University of Rochester School of Medicine and Dentistry, New York.
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MeSH Terms
Child, Preschool
Double-Blind Method
Ondansetron / therapeutic use*
Postoperative Complications / prevention & control*
Vomiting / prevention & control*
Reg. No./Substance:

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