Document Detail

Ondansetron compared with metoclopramide in the treatment of established postoperative nausea and vomiting. The French Ondansetron Study Group.
MedLine Citation:
PMID:  9389849     Owner:  NLM     Status:  MEDLINE    
We have studied 746 males and females undergoing general anaesthesia for any type of surgical procedure in a double-blind, controlled, randomized study. After experiencing at least one nausea and/or one emetic episode in the 6 h after recovery from anaesthesia, patients received either ondansetron 4 mg i.v. or metoclopramide 10 mg i.v. Patients were observed for postoperative nausea and vomiting (PONV) for 24 h after drug administration. Complete control of PONV was achieved more frequently in the ondansetron-treated patients compared with the metoclopramide-treated patients during the 24-h period (59% vs 41% (P < 0.001) and 44% vs 34% (P = 0.006) for emetic episodes and nausea, respectively). Furthermore, ondansetron was associated with greater patient satisfaction than metoclopramide (P < 0.001) with 49% and 32% of patients, respectively, very satisfied. The overall incidence of adverse events was similar in the ondansetron (7%) and metoclopramide (8%) groups. Ondansetron was as well tolerated and more effective than metoclopramide for all assessment criteria in the treatment of established PONV.
P Diemunsch; C Conseiller; N Clyti; J P Mamet
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Multicenter Study; Randomized Controlled Trial    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  79     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1997 Sep 
Date Detail:
Created Date:  1997-12-16     Completed Date:  1997-12-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  322-6     Citation Subset:  IM    
Hôpital Civil, Strasbourg, France.
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MeSH Terms
Aged, 80 and over
Anesthesia, General
Antiemetics / therapeutic use*
Double-Blind Method
Metoclopramide / therapeutic use
Middle Aged
Nausea / drug therapy*
Ondansetron / therapeutic use*
Patient Satisfaction
Postoperative Complications / drug therapy*
Vomiting / drug therapy*
Reg. No./Substance:
0/Antiemetics; 364-62-5/Metoclopramide; 99614-02-5/Ondansetron
Comment In:
Br J Anaesth. 1998 Mar;80(3):407-8   [PMID:  9623448 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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