Document Detail

Ondansetron, clinical development for postoperative nausea and vomiting: current studies and future directions.
MedLine Citation:
PMID:  7907459     Owner:  NLM     Status:  MEDLINE    
The clinical development of ondansetron for the prevention and treatment of postoperative nausea and vomiting has been progressing for 5 years, and continues as new directions of research are being addressed. Large multicentre studies have demonstrated the efficacy of ondansetron in the prevention and treatment of postoperative nausea and vomiting, but no large comparator studies have been reported. Several studies are now being undertaken to compare ondansetron with other currently used antiemetics such as droperidol and metoclopramide, assessing efficacy, safety, pharmacoeconomic, and quality of life parameters. The majority of studies to date have been performed in gynaecological surgery patients receiving general anaesthesia--a population that experiences a high incidence of postoperative nausea and vomiting. Clinical development of ondansetron is therefore progressing to establish its efficacy in a wider surgical population, including paediatrics, the elderly, non-gynaecological surgery, and as retreatment in patients with failed prophylactic antiemetic therapy.
A F Joslyn
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anaesthesia     Volume:  49 Suppl     ISSN:  0003-2409     ISO Abbreviation:  Anaesthesia     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-14     Completed Date:  1994-04-14     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0370524     Medline TA:  Anaesthesia     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  34-7     Citation Subset:  AIM; IM    
Glaxo Inc. Research Institute, Research Triangle Park, North Carolina 27709.
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MeSH Terms
Analgesics, Opioid / adverse effects
Drug Administration Schedule
Nausea / chemically induced,  drug therapy*
Ondansetron / therapeutic use*
Postoperative Complications / drug therapy*
Research Design
Vomiting / chemically induced,  drug therapy*
Reg. No./Substance:
0/Analgesics, Opioid; 99614-02-5/Ondansetron

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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