Document Detail

Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer.
MedLine Citation:
PMID:  22578566     Owner:  NLM     Status:  MEDLINE    
An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA lost in breast cancer, is directly transactivated by oncosuppressor p53. Moreover, evaluating miR-205 expression in a panel of cell lines belonging to the highly aggressive triple negative breast cancer (TNBC) subtype, which still lacks an effective targeted therapy and characterized by an extremely undifferentiated and mesenchymal phenotype, we demonstrated that this microRNA is critically down-expressed compared to a normal-like cell line. Re-expression of miR-205 where absent strongly reduces cell proliferation, cell cycle progression and clonogenic potential in vitro, and inhibits tumor growth in vivo, and this tumor suppressor activity is at least partially exerted through targeting of E2F1, master regulator of cell cycle progression, and LAMC1, component of extracellular matrix involved in cell adhesion, proliferation and migration.
Claudia Piovan; Dario Palmieri; Gianpiero Di Leva; Luca Braccioli; Patrizia Casalini; Gerard Nuovo; Monica Tortoreto; Marianna Sasso; Ilaria Plantamura; Tiziana Triulzi; Cristian Taccioli; Elda Tagliabue; Marilena V Iorio; Carlo M Croce
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-04-19
Journal Detail:
Title:  Molecular oncology     Volume:  6     ISSN:  1878-0261     ISO Abbreviation:  Mol Oncol     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-07-30     Completed Date:  2013-03-18     Revised Date:  2013-06-25    
Medline Journal Info:
Nlm Unique ID:  101308230     Medline TA:  Mol Oncol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  458-72     Citation Subset:  IM    
Copyright Information:
Published by Elsevier B.V.
Departments of Molecular Virology, Immunology and Human Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA.
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MeSH Terms
Base Sequence
Breast Neoplasms / genetics*,  pathology
Cell Aging / genetics
Cell Cycle / genetics
Cell Line, Tumor
Cell Proliferation
Down-Regulation / genetics
E2F1 Transcription Factor / metabolism
Gene Expression Regulation, Neoplastic
Laminin / metabolism
Mice, SCID
MicroRNAs / genetics*,  metabolism
Molecular Sequence Data
Protein Binding
Response Elements / genetics
Transcription, Genetic
Tumor Suppressor Protein p53 / metabolism*
Xenograft Model Antitumor Assays
Grant Support
Reg. No./Substance:
0/E2F1 Transcription Factor; 0/E2F1 protein, human; 0/Laminin; 0/MIRN205 microRNA, human; 0/MicroRNAs; 0/Tumor Suppressor Protein p53; 0/laminin gamma 1

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