| Oncosuppressive role of p53-induced miR-205 in triple negative breast cancer. | |
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MedLine Citation:
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PMID: 22578566 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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An increasing body of evidence highlights an intriguing interaction between microRNAs and transcriptional factors involved in determining cell fate, including the well known "genome guardian" p53. Here we show that miR-205, oncosuppressive microRNA lost in breast cancer, is directly transactivated by oncosuppressor p53. Moreover, evaluating miR-205 expression in a panel of cell lines belonging to the highly aggressive triple negative breast cancer (TNBC) subtype, which still lacks an effective targeted therapy and characterized by an extremely undifferentiated and mesenchymal phenotype, we demonstrated that this microRNA is critically down-expressed compared to a normal-like cell line. Re-expression of miR-205 where absent strongly reduces cell proliferation, cell cycle progression and clonogenic potential in vitro, and inhibits tumor growth in vivo, and this tumor suppressor activity is at least partially exerted through targeting of E2F1, master regulator of cell cycle progression, and LAMC1, component of extracellular matrix involved in cell adhesion, proliferation and migration. |
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Authors:
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Claudia Piovan; Dario Palmieri; Gianpiero Di Leva; Luca Braccioli; Patrizia Casalini; Gerard Nuovo; Monica Tortoreto; Marianna Sasso; Ilaria Plantamura; Tiziana Triulzi; Cristian Taccioli; Elda Tagliabue; Marilena V Iorio; Carlo M Croce |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-04-19 |
Journal Detail:
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Title: Molecular oncology Volume: 6 ISSN: 1878-0261 ISO Abbreviation: Mol Oncol Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-07-30 Completed Date: 2013-03-18 Revised Date: 2013-04-26 |
Medline Journal Info:
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Nlm Unique ID: 101308230 Medline TA: Mol Oncol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 458-72 Citation Subset: IM |
Copyright Information:
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Published by Elsevier B.V. |
Affiliation:
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Departments of Molecular Virology, Immunology and Human Genetics, Comprehensive Cancer Center, Ohio State University, Columbus, OH 43210, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Base Sequence Breast Neoplasms / genetics*, pathology Cell Aging / genetics Cell Cycle / genetics Cell Line, Tumor Cell Proliferation Down-Regulation / genetics E2F1 Transcription Factor / metabolism Female Gene Expression Regulation, Neoplastic Humans Laminin / metabolism Mice Mice, SCID MicroRNAs / genetics*, metabolism Molecular Sequence Data Protein Binding Response Elements / genetics Transcription, Genetic Tumor Suppressor Protein p53 / metabolism* Xenograft Model Antitumor Assays |
| Grant Support | |
ID/Acronym/Agency:
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U01 CA152758/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/E2F1 Transcription Factor; 0/E2F1 protein, human; 0/Laminin; 0/MIRN205 microRNA, human; 0/MicroRNAs; 0/Tumor Suppressor Protein p53; 0/laminin gamma 1 |
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