| Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells. | |
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MedLine Citation:
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PMID: 17084521 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The efficacy of Onconase on the growth of a panel of chemosensitive and chemoresistant neuroblastoma cell lines was investigated. Onconase decreased cell viability of chemosensitive (IMR-32, UKF-NB-3) and chemoresistant neuroblastoma cell lines characterised by high expression of P-glycoprotein (P-gp) (UKF-NB-3(r)DOX(20)) or by high P-gp expression in combination with mutated p53 (UKF-NB-3(r)VCR(10), Be(2)-C), in a similar manner. Moreover, Onconase caused cell cycle block in G1 phase and induced caspase-independent cell death. Transmission electron microscope investigations suggested that Onconase-induced autophagy contributes to Onconase-induced cell death. Antitumour activity of Onconase against naïve and drug-resistant neuroblastoma xenografts was confirmed in animals. |
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Authors:
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Martin Michaelis; Jaroslav Cinatl; Puja Anand; Florian Rothweiler; Rouslan Kotchetkov; Andreas von Deimling; Hans W Doerr; Kuslima Shogen; Jindrich Cinatl |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2006-11-03 |
Journal Detail:
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Title: Cancer letters Volume: 250 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 2007 May |
Date Detail:
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Created Date: 2007-04-02 Completed Date: 2007-06-26 Revised Date: 2008-11-24 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: Ireland |
Other Details:
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Languages: eng Pagination: 107-16 Citation Subset: IM |
Affiliation:
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Institut für Medizinische Virologie, Klinikum der J.W. Goethe Universität, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antineoplastic Agents / pharmacology* Caspases / metabolism* Cell Cycle Cell Death Cell Survival / drug effects Drug Resistance, Neoplasm* Female Humans Mice Mice, Nude Neuroblastoma / drug therapy*, pathology P-Glycoprotein / analysis Ribonucleases / pharmacology* Tumor Cells, Cultured Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/Antineoplastic Agents; 0/P-Glycoprotein; EC 3.1.-/Ribonucleases; EC 3.1.-/ranpirnase; EC 3.4.22.-/Caspases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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