Document Detail

Onconase induces caspase-independent cell death in chemoresistant neuroblastoma cells.
MedLine Citation:
PMID:  17084521     Owner:  NLM     Status:  MEDLINE    
The efficacy of Onconase on the growth of a panel of chemosensitive and chemoresistant neuroblastoma cell lines was investigated. Onconase decreased cell viability of chemosensitive (IMR-32, UKF-NB-3) and chemoresistant neuroblastoma cell lines characterised by high expression of P-glycoprotein (P-gp) (UKF-NB-3(r)DOX(20)) or by high P-gp expression in combination with mutated p53 (UKF-NB-3(r)VCR(10), Be(2)-C), in a similar manner. Moreover, Onconase caused cell cycle block in G1 phase and induced caspase-independent cell death. Transmission electron microscope investigations suggested that Onconase-induced autophagy contributes to Onconase-induced cell death. Antitumour activity of Onconase against naïve and drug-resistant neuroblastoma xenografts was confirmed in animals.
Martin Michaelis; Jaroslav Cinatl; Puja Anand; Florian Rothweiler; Rouslan Kotchetkov; Andreas von Deimling; Hans W Doerr; Kuslima Shogen; Jindrich Cinatl
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-11-03
Journal Detail:
Title:  Cancer letters     Volume:  250     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-04-02     Completed Date:  2007-06-26     Revised Date:  2008-11-24    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  107-16     Citation Subset:  IM    
Institut für Medizinische Virologie, Klinikum der J.W. Goethe Universität, Paul Ehrlich-Str. 40, 60596 Frankfurt am Main, Germany.
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MeSH Terms
Antineoplastic Agents / pharmacology*
Caspases / metabolism*
Cell Cycle
Cell Death
Cell Survival / drug effects
Drug Resistance, Neoplasm*
Mice, Nude
Neuroblastoma / drug therapy*,  pathology
P-Glycoprotein / analysis
Ribonucleases / pharmacology*
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Reg. No./Substance:
0/Antineoplastic Agents; 0/P-Glycoprotein; EC 3.1.-/Ribonucleases; EC 3.1.-/ranpirnase; EC 3.4.22.-/Caspases

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