Document Detail

OncomiRDB: a database for the experimentally verified oncogenic and tumor-suppressive microRNAs.
MedLine Citation:
PMID:  24651967     Owner:  NLM     Status:  Publisher    
SUMMARY: MicroRNAs (miRNAs), a class of small regulatory RNAs, play important roles in cancer initiation, progression and therapy. MiRNAs are found to regulate diverse cancer-related processes by targeting a large set of oncogenic and tumor-suppressive genes. To establish a high-confidence reference resource for studying the miRNA regulated target genes and cellular processes in cancer, we manually curated 2,259 entries of cancer-related miRNA regulations with direct experimental evidences from ~9,000 abstracts, covering over 300 miRNAs and 829 target genes across 25 cancer tissues. A web-based portal named oncomiRDB, which provides both graphical and text-based interfaces, was developed for easily database browsing and searching. It should be a useful resource for both the computational analysis and experimental study on miRNA regulatory networks and functions in cancer.
Dongfang Wang; Jin Gu; Ting Wang; Zijian Ding
Related Documents :
23341177 - Epigenetic alterations in colorectal cancer: the cpg island methylator phenotype.
25109877 - Multiplatform analysis of 12 cancer types reveals molecular classification within and a...
20584627 - An exploration of public knowledge of warning signs for cancer.
24965397 - A missense mutation (s3660l) in mll3 gene influences risk of gastric cancer.
23660117 - Recruiting women for a study on perceived risk of cancer: influence of survey topic sal...
17312467 - Statins reduce the risk of pancreatic cancer in humans: a case-control study of half a ...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-20
Journal Detail:
Title:  Bioinformatics (Oxford, England)     Volume:  -     ISSN:  1367-4811     ISO Abbreviation:  Bioinformatics     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808944     Medline TA:  Bioinformatics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Particle shape effects on the stress response of granular packings.
Next Document:  tqDist: A Library for Computing the Quartet and Triplet Distances Between Binary or General Trees.