Document Detail


OncomiRDB: a database for the experimentally verified oncogenic and tumor-suppressive microRNAs.
MedLine Citation:
PMID:  24651967     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
SUMMARY: MicroRNAs (miRNAs), a class of small regulatory RNAs, play important roles in cancer initiation, progression and therapy. MiRNAs are found to regulate diverse cancer-related processes by targeting a large set of oncogenic and tumor-suppressive genes. To establish a high-confidence reference resource for studying the miRNA regulated target genes and cellular processes in cancer, we manually curated 2,259 entries of cancer-related miRNA regulations with direct experimental evidences from ~9,000 abstracts, covering over 300 miRNAs and 829 target genes across 25 cancer tissues. A web-based portal named oncomiRDB, which provides both graphical and text-based interfaces, was developed for easily database browsing and searching. It should be a useful resource for both the computational analysis and experimental study on miRNA regulatory networks and functions in cancer.
AVAILABILITY: http://bioinfo.au.tsinghua.edu.cn/oncomirdb/ CONTACT: jgu@tsinghua.edu.cn.
Authors:
Dongfang Wang; Jin Gu; Ting Wang; Zijian Ding
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-20
Journal Detail:
Title:  Bioinformatics (Oxford, England)     Volume:  -     ISSN:  1367-4811     ISO Abbreviation:  Bioinformatics     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-21     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9808944     Medline TA:  Bioinformatics     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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