| Oncologic applications of diffusion-weighted MRI in the body. | |
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MedLine Citation:
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PMID: 22271274 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Diffusion-weighted MRI (DWI) allows the detection of malignancies in the abdomen and pelvis. Lesion detection and characterization using DWI largely depends on the increased cellularity of solid or cystic lesions compared with the surrounding tissue. This increased cellularity leads results in restricted diffusion as indicated by reduction in the apparent diffusion coefficient (ADC). Low pretreatment ADC values of several malignancies have been shown to be predictive of better outcome. DWI can assess response to systemic or regional treatment of cancer at a cellular level and will therefore detect successful treatment earlier than anatomical measures. In this review, we provide a brief technical overview of DWI, discuss quantitative image analysis approaches, and review studies which have used DWI for the purpose of detection and characterization of malignancies as well as the early prediction of treatment response. J. Magn. Reson. Imaging 2012;257-279. © 2011 Wiley Periodicals, Inc. |
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Authors:
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Susanne Bonekamp; Celia P Corona-Villalobos; Ihab R Kamel |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 35 ISSN: 1522-2586 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2012 Feb |
Date Detail:
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Created Date: 2012-01-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 257-79 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Wiley Periodicals, Inc. |
Affiliation:
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The Russell H. Morgan Department of Radiology and Radiological Science Johns Hopkins University, Baltimore, Maryland, USA. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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