Document Detail


Oncogenically activated or ligand-stimulated neu kinase stimulates neurite outgrowth in PC12 cells.
MedLine Citation:
PMID:  7915994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Retroviral vectors pDOL/NeuN and pDOL/NeuT were used to express normal and transforming rat neu cDNAs in PC12 cells. DOL/NeuT-infected cells exhibited a high frequency of spontaneous neurite outgrowth while DOL/NeuN-infected cells showed neurite outgrowth in the presence of heregulin, a putative ligand for the neu receptor tyrosine kinase. In both cases, neurite outgrowth was preceded by phosphorylation of p185neu and several other cellular proteins. Thus the neu tyrosine kinase can elicit morphological and biochemical changes resembling, but distinct from, those stimulated by NGF, and heregulin stimulates neu to elicit these effects in PC12 cells.
Authors:
D C Gamett; R A Cerione
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  FEBS letters     Volume:  351     ISSN:  0014-5793     ISO Abbreviation:  FEBS Lett.     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1994-10-13     Completed Date:  1994-10-13     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0155157     Medline TA:  FEBS Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  335-9     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, New York State College of Veterinary Medicine, Cornell University, Ithaca 14853-6401.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bucladesine / pharmacology
Cells, Cultured
DNA, Complementary
Enzyme Activation
Glycoproteins / pharmacology
Ligands
Nerve Growth Factors / pharmacology
Neuregulins
Neurites*
PC12 Cells
Phosphorylation
Proto-Oncogene Proteins / metabolism*
Rats
Receptor, Epidermal Growth Factor / metabolism*
Receptor, erbB-2
Retroviridae
Tetradecanoylphorbol Acetate / pharmacology
Tyrosine / metabolism
Vanadates / pharmacology
Grant Support
ID/Acronym/Agency:
40654//PHS HHS
Chemical
Reg. No./Substance:
0/DNA, Complementary; 0/Glycoproteins; 0/Ligands; 0/Nerve Growth Factors; 0/Neuregulins; 0/Proto-Oncogene Proteins; 0/Vanadates; 16561-29-8/Tetradecanoylphorbol Acetate; 362-74-3/Bucladesine; 55520-40-6/Tyrosine; EC 2.7.10.1/Receptor, Epidermal Growth Factor; EC 2.7.10.1/Receptor, erbB-2

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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