| Oncogenic K-Ras requires activation for enhanced activity. | |
| | |
MedLine Citation:
|
PMID: 23334325 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Oncogenic Ras mutations are widely considered to be locked in a permanent 'On' state and 'constitutively active'. Yet, many healthy people have cells possessing mutant Ras without apparent harm, and in animal models mutant Ras causes transformation only after upregulation of Ras activity. Here, we demonstrate that oncogenic K-Ras is not constitutively active but can be readily activated by upstream stimulants to lead to prolonged strong Ras activity. These data indicate that in addition to targeting K-Ras downstream effectors, interventions to reduce K-Ras activation may have important cancer-preventive value, especially in patients with oncogenic Ras mutations. As other small G proteins are regulated in a similar manner, this concept is likely to apply broadly to the entire Ras family of molecules.Oncogene advance online publication, 21 January 2013; doi:10.1038/onc.2012.619. |
| | |
Authors:
|
H Huang; J Daniluk; Y Liu; J Chu; Z Li; B Ji; C D Logsdon |
Related Documents
:
|
19373855 - Activation of the erk/mapk pathway: a signature genetic defect in posterior fossa piloc... 19243475 - Serum regulates adipogenesis of mesenchymal stem cells via mek/erk-dependent ppargamma ... 12946695 - Activation of the mitogen-activated protein kinase/extracellular signal-regulated kinas... 17065055 - Inhibition of the erk pathway promotes apoptosis induced by 2-chloro-2'-deoxyadenosine ... 3160705 - Activation of protein kinase c by triton x-100 mixed micelles containing diacylglycerol... 2153115 - Selective killing of klebsiella pneumoniae by 5-trifluoromethylthioribose. chemotherape... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2013-1-21 |
Journal Detail:
|
Title: Oncogene Volume: - ISSN: 1476-5594 ISO Abbreviation: Oncogene Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8711562 Medline TA: Oncogene Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
1] Department of Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, TX, USA [2] Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai, China. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Role for Prdx1 as a specific sensor in redox-regulated senescence in breast cancer.
Next Document: The mitotic kinase Aurora-A promotes distant metastases by inducing epithelial-to-mesenchymal transi...