| Oncogenic H-Ras, FK228, and exogenous H(2) O(2) cooperatively activated the erk pathway in selective induction of human urinary bladder cancer j82 cell death. | |
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MedLine Citation:
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PMID: 21344509 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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More than 35% of human urinary bladder cancers involve oncogenic H-Ras activation. The goal of this study was to investigate the role of the ERK pathway in mediating apoptotic signals induced by oncogenic H-Ras, FK228 treatment, and exogenous H(2) O(2) treatment to increase Nox-1 elevation, leading to production of intracellular reactive oxygen species (ROS) for inducing apoptosis in human bladder cancer J82 cells. Our study revealed that FK228 combined with exogenous H(2) O(2) cooperatively induced activation of Mek1/2 and Erk1/2 to increase Nox-1 elevation, intracellular ROS production, caspase activation, and cell death. Expression of oncogenic H-Ras significantly increased these FK228- and exogenous H(2) O(2) -induced effects. Oncogenic H-Ras-increased cell susceptibility to FK228 could be alternately achieved by additional treatment with exogenous H(2) O(2) . Hence, combined use of FK228 with ROS-generating agents may apply to therapeutic strategies to preferentially kill malignant cells with or without oncogenic H-Ras activation. ©2010 Wiley-Liss, Inc. |
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Authors:
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Shambhunath Choudhary; Kwo-Kwang Abraham Wang; Hwa-Chain Robert Wang |
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Publication Detail:
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Type: Journal Article Date: 2010-12-28 |
Journal Detail:
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Title: Molecular carcinogenesis Volume: 50 ISSN: 1098-2744 ISO Abbreviation: Mol. Carcinog. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8811105 Medline TA: Mol Carcinog Country: United States |
Other Details:
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Languages: eng Pagination: 215-9 Citation Subset: IM |
Copyright Information:
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Copyright ©2010 Wiley-Liss, Inc. |
Affiliation:
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Department of Comparative Medicine, Anticancer Molecular Oncology Laboratory, College of Veterinary Medicine, The University of Tennessee, Knoxville, Tennessee. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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