| Oncogene-induced senescence and melanoma: where do we stand? | |
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MedLine Citation:
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PMID: 22018309 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In recent years, many groups have detected biomarkers of cellular senescence in a plethora of neoplastic lesions, in model systems and humans. Indeed, we have come to realize that oncogene-induced senescence (OIS) acts as a potent barrier to oncogenic transformation, operating alongside cell death programs. We have begun to uncover some of its underlying principles, but many fundamental questions remain. In this perspective, some of the "knowns" and "unknowns" of OIS are discussed, with a focus on melanomagenesis. |
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Authors:
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Daniel S Peeper |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-10-22 |
Journal Detail:
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Title: Pigment cell & melanoma research Volume: - ISSN: 1755-148X ISO Abbreviation: - Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101318927 Medline TA: Pigment Cell Melanoma Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011 John Wiley & Sons A/S. |
Affiliation:
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Netherlands Cancer Institute, Division of Molecular Genetics. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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