| Oncogene-induced senescence: the bright and dark side of the response. | |
| | |
MedLine Citation:
|
PMID: 20807678 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
In late 1990s, it was shown that activated oncogenes are able to induce senescence. Since then large leaps in understanding this phenomenon have been achieved. There is substantial evidence supporting oncogene-induced senescence (OIS) as a potent antitumor barrier in vivo. Multiple pathways participating in cell cycle regulation, DNA damage signaling, immune response, and bioenergetics regulate the process. Despite its beneficial effects the senescent cell is thought to promote carcinogenesis and age-related disease in a nonautonomous manner. Here, we highlight the works dealing with all these aspects and discuss the studies proposing therapeutic exploitation of OIS. |
| | |
Authors:
|
Vassilis G Gorgoulis; Thanos D Halazonetis |
Related Documents
:
|
9223108 - Changes in apoptosis of human polymorphonuclear granulocytes with aging. 18850188 - Zinc-gene interaction related to inflammatory/immune response in ageing. 18660678 - The noncalciotropic actions of vitamin d: recent clinical developments. 14580308 - Role of redox imbalance in the molecular mechanisms responsible for immunosenescence. 18405958 - The extended il-10 superfamily: il-10, il-19, il-20, il-22, il-24, il-26, il-28, and il... 11823528 - Inflammatory response and glutathione peroxidase in a model of stroke. |
Publication Detail:
|
Type: Journal Article Date: 2010-09-16 |
Journal Detail:
|
Title: Current opinion in cell biology Volume: 22 ISSN: 1879-0410 ISO Abbreviation: Curr. Opin. Cell Biol. Publication Date: 2010 Dec |
Date Detail:
|
Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8913428 Medline TA: Curr Opin Cell Biol Country: England |
Other Details:
|
Languages: eng Pagination: 816-27 Citation Subset: IM |
Copyright Information:
|
Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
|
Molecular Carcinogenesis Group, Department of Histology and Embryology, School of Medicine, University of Athens, Athens, Greece. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Anatomical and immunohistochemical considerations on the microinnervation of trachea in humans.
Next Document: A spectroscopic comparison of selected Chinese kaolinite, coal bearing kaolinite and halloysite--a m...