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Oncocytic adrenal cortical carcinosarcoma with pleomorphic rhabdomyosarcomatous metastases.
MedLine Citation:
PMID:  22343339     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Adrenal cortical carcinosarcoma is a rare variant of adrenal cortical carcinoma. Sarcomatous change in adrenal cortical carcinomas is exceptionally rare, with only 9 cases previously described. Adrenal cortical carcinosarcomas tend to be aggressive tumors, with locoregional recurrence and rapid metastases from the sarcomatoid component. We describe what seems to be the first case of sarcoma arising in oncocytic adrenal cortical carcinoma. The sarcomatous component here was pleomorphic rhabdomyosarcoma. This occurred in a 45-year-old man who had nodal and pulmonary metastases of the rhabdomyosarcomatous component at presentation and who died of progressive disease 11 months later. Here, we discuss the clinical, radiologic, and pathologic findings and review the literature on adrenal cortical carcinosarcomas.
Authors:
Khin Thway; David Olmos; Chirag Shah; Rashpal Flora; Janet Shipley; Cyril Fisher
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of surgical pathology     Volume:  36     ISSN:  1532-0979     ISO Abbreviation:  Am. J. Surg. Pathol.     Publication Date:  2012 Mar 
Date Detail:
Created Date:  2012-02-20     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7707904     Medline TA:  Am J Surg Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  470-7     Citation Subset:  IM    
Affiliation:
*Sarcoma Unit, Department of Histopathology, The Royal Marsden NHS Foundation Trust, London †Sarcoma Molecular Pathology Team, Divisions of Molecular Pathology and Cancer Therapeutics, The Institute of Cancer Research ‡Sarcoma Unit, Drug Development and Medical Oncology Units, The Royal Marsden NHS Foundation Trust, Sutton, Surrey, UK.
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