Document Detail

Oncocytes, oxyphils, H?rthle, and Askanazy cells: morphological and molecular features of oncocytic thyroid nodules.
MedLine Citation:
PMID:  20013317     Owner:  NLM     Status:  MEDLINE    
Our understanding of oncocytic change in thyroid nodules is evaluated in light of the recent progress in understanding the mitochondrial DNA, its mutations, and somatic mutations that affect mitochondrial function. These changes are largely unrelated to the genetic events that result in proliferation and neoplastic transformation of thyroid follicular epithelial cells. The criteria for diagnosing lesions that are composed predominantly of oncocytic cells are the same as those applied to follicular lesions that do not contain oncocytic cells, including follicular variant papillary carcinomas, based on nuclear morphology, immunohistochemical profiles, and molecular markers.
Ozgur Mete; Sylvia L Asa
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Endocrine pathology     Volume:  21     ISSN:  1559-0097     ISO Abbreviation:  Endocr. Pathol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-09     Completed Date:  2010-06-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009288     Medline TA:  Endocr Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-24     Citation Subset:  IM    
Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, M5G 2C4, Canada.
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MeSH Terms
Cell Differentiation / physiology
DNA, Mitochondrial / genetics
DNA, Neoplasm / genetics
Mitochondria / genetics,  pathology,  ultrastructure
Oxyphil Cells / pathology*,  ultrastructure
Thyroid Nodule / diagnosis,  genetics,  pathology*,  ultrastructure
Reg. No./Substance:
0/DNA, Mitochondrial; 0/DNA, Neoplasm

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