| Oncocytes, oxyphils, H?rthle, and Askanazy cells: morphological and molecular features of oncocytic thyroid nodules. | |
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MedLine Citation:
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PMID: 20013317 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our understanding of oncocytic change in thyroid nodules is evaluated in light of the recent progress in understanding the mitochondrial DNA, its mutations, and somatic mutations that affect mitochondrial function. These changes are largely unrelated to the genetic events that result in proliferation and neoplastic transformation of thyroid follicular epithelial cells. The criteria for diagnosing lesions that are composed predominantly of oncocytic cells are the same as those applied to follicular lesions that do not contain oncocytic cells, including follicular variant papillary carcinomas, based on nuclear morphology, immunohistochemical profiles, and molecular markers. |
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Authors:
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Ozgur Mete; Sylvia L Asa |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Endocrine pathology Volume: 21 ISSN: 1559-0097 ISO Abbreviation: Endocr. Pathol. Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-09 Completed Date: 2010-06-08 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9009288 Medline TA: Endocr Pathol Country: United States |
Other Details:
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Languages: eng Pagination: 16-24 Citation Subset: IM |
Affiliation:
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Department of Pathology, University Health Network, 200 Elizabeth Street, 11th floor, Toronto, ON, M5G 2C4, Canada. ozgurmete77@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Cell Differentiation
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physiology DNA, Mitochondrial / genetics DNA, Neoplasm / genetics Humans Mitochondria / genetics, pathology, ultrastructure Oxyphil Cells / pathology*, ultrastructure Thyroid Nodule / diagnosis, genetics, pathology*, ultrastructure |
| Chemical | |
Reg. No./Substance:
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0/DNA, Mitochondrial; 0/DNA, Neoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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