| Once-nightly treatment with pirenzepine or cimetidine for peptic ulcers: a multicentre, randomised, double blind, controlled study. | |
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MedLine Citation:
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PMID: 3330601 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixty-nine patients with symptomatic and endoscopically diagnosed gastric or duodenal ulcers received treatment with either pirenzepine 100 mg or cimetidine 800 mg one hour before bedtime in a prospective randomised, double blind study. Fifty-five patients completed the six weeks treatment period of whom 13/15 (87%) gastric ulcers and 13/16 (81%) duodenal ulcers, healed with pirenzepine compared to 8/11 (73%) gastric ulcers and 10/13 (77%) duodenal ulcers treated with cimetidine for the same period. The differences in healing rates between pirenzepine and cimetidine were not statistically significant. Pirenzepine 100 mg administered at night is therefore an effective treatment for gastric and duodenal ulcers. |
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Authors:
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D P Edge; P Brown; K Luey; N H Stace |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The New Zealand medical journal Volume: 100 ISSN: 0028-8446 ISO Abbreviation: N. Z. Med. J. Publication Date: 1987 Nov |
Date Detail:
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Created Date: 1988-07-28 Completed Date: 1988-07-28 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401067 Medline TA: N Z Med J Country: NEW ZEALAND |
Other Details:
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Languages: eng Pagination: 705-7 Citation Subset: IM |
Affiliation:
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Palmerston North Hospital. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Cimetidine / administration & dosage*, adverse effects, therapeutic use Clinical Trials as Topic Double-Blind Method Drug Administration Schedule Female Humans Male Middle Aged Peptic Ulcer / drug therapy* Pirenzepine / administration & dosage*, adverse effects, therapeutic use Prospective Studies Random Allocation |
| Chemical | |
Reg. No./Substance:
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28797-61-7/Pirenzepine; 51481-61-9/Cimetidine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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