Document Detail

Once-daily use of glyburide.
MedLine Citation:
PMID:  3931465     Owner:  NLM     Status:  MEDLINE    
Ideally, metabolic control with sulfonylureas should be maintained for 24 hours. To determine an optimal glyburide dosage schedule, the effects of glyburide once (every morning) or twice daily and chlorpropamide once daily (every morning) were compared in 18 men with non-insulin-dependent diabetes mellitus in a randomized, double-blind fashion. After discontinuation of previous hypoglycemic agents for 10 days, patients were admitted to a metabolic ward for two weeks (Study A). Glycemic measurements were performed on Day 14. Subjects were readmitted after 12 weeks of outpatient therapy for another two weeks (Study B), and glycemic determinations were repeated. Weight was kept constant during and between Studies A and B. Effective hypoglycemic action of each drug regimen was demonstrated. When six glycemic parameters were compared, there was no significant difference between groups. Thus, over a 14-week period, both glyburide regimens were similar and as effective as chlorpropamide once daily.
P Ginier; S Madan; F Fajardo; S R Levin
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of medicine     Volume:  79     ISSN:  0002-9343     ISO Abbreviation:  Am. J. Med.     Publication Date:  1985 Sep 
Date Detail:
Created Date:  1985-11-14     Completed Date:  1985-11-14     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0267200     Medline TA:  Am J Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  72-7     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Glucose
Body Weight
Chlorpropamide / therapeutic use
Diabetes Mellitus, Type 2 / drug therapy*
Drug Administration Schedule
Glucagon / blood
Glyburide / administration & dosage*
Glycosuria / diagnosis
Insulin / blood
Grant Support
Reg. No./Substance:
0/Blood Glucose; 10238-21-8/Glyburide; 11061-68-0/Insulin; 9007-92-5/Glucagon; 94-20-2/Chlorpropamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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